Expression of nNOS and soluble guanylate cyclase in schizophrenic brain
Expression of nNOS and soluble guanylate cyclase in schizophrenic brain
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DOI：
10.1097/00001756-200403220-00020
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发表时间：
2004-03-22
期刊：
影响因子：
1.7
通讯作者：
Emson, PC
中科院分区：
文献类型：
--
作者：
Baba, H;Suzuki, T;Emson, PC
最近的证据表明，一氧化氮（NO）系统在精神分裂症的病理生理学中受到影响。我们使用实时定量 PCR 定量了精神分裂症患者和对照组死后大脑前额皮质中神经元 NO 合酶 (nNOS) 和可溶性鸟苷酸环化酶 (sGC) 亚基 mRNA 的水平，以确定“精神分裂症”大脑中 nNOS 和 sGC 亚基的水平是否发生改变。精神分裂症患者的前额皮质神经元 NOS 表达显着较高，而精神分裂症患者或对照组的 sGC 亚基 mRNA 没有发现显着变化。大脑中 nNOS 表达异常可能会导致精神分裂症的发生。
Recent evidence suggests that nitric oxide (NO) systems are affected in the pathophysiology of schizophrenia. We quantified levels of neuronal NO synthase (nNOS) and soluble guanylate cyclase (sGC) subunit mRNAs in the prefrontal cortex of postmortem brains from individuals with schizophrenia and controls using real-time quantitative PCR, to determine whether levels of nNOS and sGC subunits are altered in 'schizophrenic' brains. Neuronal NOS expression in the prefrontal cortex was significantly higher in individuals with schizophrenia, whereas no significant changes were found in sGC subunit mRNAs in people with schizophrenia or in controls. Abnormalities of nNOS expression in the brain might contribute to the development of schizophrenia.