Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
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DOI：
10.1016/s1044-7431(03)00159-3
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发表时间：
2003-09-01
影响因子：
3.5
通讯作者：
Greenberg, DA
中科院分区：
文献类型：
--
作者：
Jin, K;Sun, YJ;Greenberg, DA
病理过程，包括脑缺血，可以增强成人大脑中的神经发生，但产生的新生神经元的命运及其在大脑修复中的作用尚不清楚。为了确定缺血诱导的神经元增殖是否与新生神经元向缺血性病变的迁移有关，我们绘制了由细胞增殖标记物和神经元标记蛋白抗体标记的细胞迁移图，在大脑中动脉闭塞引起的局灶性脑缺血90分钟发作后长达2周。双皮质素免疫反应细胞在头侧脑室下区，但不是齿状回，迁移到缺血半暗带相邻的纹状体，并通过头侧迁移流和外侧皮质流，进入缺血半暗带的皮质。这些结果表明，脑缺血后，新的神经元被定向到脑损伤的部位，在那里它们可能处于参与脑修复和功能恢复的位置。(C)2003 Elsevier Science（美国）。All rights reserved.
Pathological processes, including cerebral ischemia, can enhance neurogenesis in the adult brain, but the fate of the newborn neurons that are produced and their role in brain repair are obscure. To determine if ischemia-induced neuronal proliferation is associated with migration of nascent neurons toward ischemic lesions, we mapped the migration of cells labeled by cell proliferation markers and antibodies against neuronal marker proteins, for up to 2 weeks after a 90-min episode of focal cerebral ischemia caused by occlusion of the middle cerebral artery. Doublecortin-immunoreactive cells in the rostral subventricular zone, but not the dentate gyrus, migrated into the ischemic penumbra of the adjacent striatum and, via the rostral migratory stream and lateral cortical stream, into the penumbra of ischemic cortex. These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery. (C) 2003 Elsevier Science (USA). All rights reserved.