HMGA1 protein overexpression in human breast carcinomas: Correlation with ErbB2 expression
HMGA1 protein overexpression in human breast carcinomas: Correlation with ErbB2 expression
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DOI：
10.1158/1078-0432.ccr-04-0291
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发表时间：
2004-11-15
影响因子：
11.5
通讯作者：
Fusco, A
中科院分区：
文献类型：
--
作者：
Chiappetta, G;Botti, G;Fusco, A
我们测量，通过免疫组化，HMGA 1蛋白表达在212乳腺组织标本：6个正常样本，28增生病变（13与细胞增生），11纤维腺瘤，10原位导管癌，144导管癌，和13小叶癌。HMGA 1在正常乳腺组织中不表达; HMGA 1在40%的增生性病变伴细胞增生和60%的导管癌中染色强烈，在纤维腺瘤和增生性病变中染色较弱，而无细胞增生。由于HMGA 1表达在不同组织学分级的乳腺导管癌中相似，我们在21例3级乳腺导管癌和7例乳腺小叶癌中评估了HMGA 1表达与其他乳腺癌浸润标志物（雌激素和孕激素受体、Ki-67抗原和ErbB 2）之间的相关性。我们发现HMGA 1表达倾向于仅与c-erbB-2表达相关（斯皮尔曼rho：0.36; P = 0.065）。这些结果表明，HMGA 1的表达可能是一个新的指标，为人类乳腺癌的诊断和预后。
We measured, by immunohistochemistry, HMGA1 protein expression in 212 breast tissue specimens: 6 normal samples, 28 hyperplastic lesions (13 with cellular atypia), 11 fibroadenomas, 10 in situ ductal carcinomas, 144 ductal carcinomas, and 13 lobular carcinomas. HMGA1 was not expressed in normal breast tissue; HMGA1 staining was intense in 40% of hyperplastic lesions with cellular atypia and in 60% of ductal carcinomas and weak in fibroadenomas and in hyperplastic lesions without cellular atypia. Because HMGA1 expression was similar among ductal breast carcinomas with different histologic grading, we evaluated the association between HMGA1 expression and that of other markers of breast carcinoma invasion (estrogen and progesterone receptors, Ki-67 antigen, and ErbB2) in 21 cases of grade 3 breast ductal carcinomas and 7 cases of breast lobular carcinomas. We found that HMGA1 expression tended to be associated only with c-erbB-2 expression (Spearman rho: 0.36; P = 0.065). Taken together, these results suggest that HMGA1 expression might be a novel indicator for the diagnosis and prognosis of human breast cancer.