Glomerular filtration rate: Assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney
Glomerular filtration rate: Assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney
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DOI：
10.1002/jmri.20173
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发表时间：
2004-11-01
影响因子：
4.4
通讯作者：
Van Beers, BE
中科院分区：
文献类型：
--
作者：
Annet, L;Hermoye, L;Van Beers, BE
目的：应用MRI和皮质室模型测量肾小球滤过率(GFR)，并与Patlak-Rutland模型的结果进行比较。材料和方法：在注射加多特罗地葡胺的过程中和之后，对兔肾脏进行动态MRI检查。用皮质室模型和Patlak-Rutland模型分析主动脉和肾脏的增强曲线。结果：用皮质室模型测量的肾小球滤过率与血浆~(51)Cr-乙二胺四乙胺清除量之间存在显著的相关性(r=0.821，P=0.004)。在肾皮质和髓质周围的感兴趣区(ROI)，~(51)Cr-EDTA清除量(r=0.628，P=0.052)与Patlak-Rutland模型计算的肾小球滤过率之间无显著相关性。Bland和Altman分析表明，当感兴趣区仅限于皮质时，GFR(皮质)室比GFR(Patlak)更符合51Cr-EDTA清除。然而，MRI获得的GFR值低于51Cr-EDTA的血浆清除值。结论：采用皮质-室模型的MRI比Patlak-Rutland模型提供了更准确的肾小球滤过评估。(C)2004年Wiley-Liss公司
Purpose: To describe the use of MRI and a cortical-compartment model to measure the glomerular filtration rate (GFR), and compare the results with those obtained with the Patlak-Rutland model.Materials and Methods: Dynamic MRI of rabbit kidneys was performed during and after injection of gadoterate dimeglumine. The enhancement curves in the aorta and the kidney were analyzed with the cortical-compartment and Patlak-Rutland models to assess the GFR.Results: A substantial correlation was observed between the GFR measured with MRI using the cortical-compartment model and the plasma clearance of 51Cr-EDTA (r = 0.821, P = 0.004). No significant correlation was observed between the 51Cr-EDTA clearance (r = 0.628, P = 0.052) and the GFR obtained with the Patlak-Rutland model in regions of interest (ROIs) encompassing the renal cortex and medulla. A Bland and Altman analysis showed that GFR(cortical) compartment agreed better with the 51Cr-EDTA clearance compared to GFR(Patlak) when ROIs were limited to the cortex. However, the GFR values obtained by MRI were lower than the plasma clearance of 51Cr-EDTA.Conclusion: MRI with a cortical-compartment model provides more accurate assessments of glomerular filtration than the Patlak-Rutland model. (C) 2004 Wiley-Liss, Inc.