Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra
Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra
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DOI：
10.1097/00001756-199702100-00014
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发表时间：
1997-02-10
期刊：
影响因子：
1.7
通讯作者：
Wu, XF
中科院分区：
文献类型：
--
作者：
French, ED;Dillon, K;Wu, XF
细胞外记录用于确定大麻素对腹侧被盖区（VTA）和黑质背侧部（SNC）内多巴胺神经元活性的影响。（Δ 9-THC）和大麻模拟物氨基烷基吲哚WIN 55，212-2在两个神经元群体中产生放电率和爆发放电的剂量依赖性增加。这些作用似乎是特异性的，因为非精神活性大麻二酚和无活性对映体WIN 55，212 -3未能改变神经元兴奋性的任一参数。此外，VTA中的多巴胺神经元比SNC中的多巴胺神经元对Delta 9-THC的刺激作用更敏感。这些结果可能提供了一种机制，通过这种机制，精神活性大麻素增加了中脑边缘和纹状体组织中的细胞外多巴胺水平，从而有助于大麻的强化作用。
EXTRACELLULAR recordings were used to determine the effects of cannabinoids on the activity of dopamine neurons within the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC), Systemic administration of the natural psychoactive cannabinoid Delta 9-tetrahydrocannabinol (Delta 9-THC) and the cannabimimetic aminoalkylindole WIN 55,212-2 produced dose-dependent increases in firing rate and burst firing in both neuronal populations. These effects appear to be specific as the non-psychoactive cannabidiol and the inactive enantiomer WIN 55,212-3 failed to alter either parameter of neuronal excitability. Furthermore, dopamine neurons in the VTA were more sensitive than those in the SNC to the stimulatory actions of Delta 9-THC. These results may provide a mechanism by which psychoactive cannabinoids increase extracellular dopamine levels in mesolimbic and striatal tissues, and thereby contribute to the reinforcing effects of marijuana.