Olfactory-evoked regional cerebral blood flow in Alzheimer's disease
Olfactory-evoked regional cerebral blood flow in Alzheimer's disease
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DOI：
10.1037//0894-4105.15.1.18
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发表时间：
2001-01-01
期刊：
影响因子：
2.4
通讯作者：
Hutchins, GD
中科院分区：
文献类型：
--
作者：
Kareken, DA;Doty, RL;Hutchins, GD
嗅觉在阿尔茨海默病（AD）中受损。据推测，AD将减少内侧颞叶嗅觉（梨状）皮层中的嗅觉诱发灌注，神经病理学开始于此。7例AD患者和8例老年对照（EC）在正电子发射断层扫描过程中进行嗅觉阈值和识别测试和嗅觉刺激。在AD中气味识别受损。但阈值不是。嗅刺激EC激活右侧和左侧梨状区和右侧前腹侧颞叶皮层。AD患者右侧梨状核和前腹侧颞叶皮质激活较少，而左侧梨状核区无激活。而眶皮层在内皮细胞中无激活。在这方面，两组之间存在显著差异。右侧梨状核激活与气味识别相关。受损的气味识别可能反映了感觉皮层功能障碍，而不是认知障碍。嗅球投射到内侧颞叶。功能成像期间的嗅觉刺激可检测该区域的早期功能障碍。
Olfaction is impaired in Alzheimer's disease (AD). It was hypothesized that AD would reduce olfactory-evoked perfusion in mesial temporal olfactory (piriform) cortex, where neuropathology begins. Seven AD patients and 8 elderly controls (ECs) underwent olfactory threshold and identification tests and olfactory stimulation during positron emission tomography. Odor identification was impaired in AD. but threshold was not. Olfactory stimulation in ECs activated right and left piriform areas and right anterior ventral temporal cortex. AD patients had less activation in right piriform and anterior ventral temporal cortex but not in the left piriform area. Although orbital cortex did not activate in ECs. there was a significant between-groups difference in this area. Right piriform activation correlated with odor identification. impaired odor identification likely reflects sensory cortex dysfunction rather than cognitive impairment. Given olfactory bulb projections to the mesial temporal lobe. olfactory stimulation during functional imaging might detect early dysfunction in this region.