Diastereoselective Michael initiated ring closure on vinyl sulfone-modified carbohydrates:: A stereospecific and general route to α-substituted cyclopropanes
Diastereoselective Michael initiated ring closure on vinyl sulfone-modified carbohydrates:: A stereospecific and general route to α-substituted cyclopropanes
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DOI：
10.1021/jo701378d
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发表时间：
2007-11-23
影响因子：
3.6
通讯作者：
Pathak, Tanmaya
中科院分区：
文献类型：
--
作者：
Das, Indrajit;Pal, Tarun K.;Pathak, Tanmaya
[图形]适当设计的乙烯基砜修饰的呋喃糖苷作为迈克尔引发的闭环反应的底物，产生环丙烷化的碳水化合物。该策略本质上是通用的，并且可以获得在三个连续碳上具有预定手性的环丙烷，其中在α-位置具有不同的取代基。
[Graphics]Suitably designed vinyl sulfone-modified furanosides act as substrates for Michael initiated ring closure reactions yielding cyclopropanated carbohydrates. The strategy is general in nature and gives access to cyclopropanes with predefined chiralities on three consecutive carbons with varying substitutions at the alpha-position.