Pseudomonas aeruginosa in the home environment of newly infected cystic fibrosis patients
Pseudomonas aeruginosa in the home environment of newly infected cystic fibrosis patients
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DOI：
10.1183/09031936.00088907
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发表时间：
2008-04-01
影响因子：
24.3
通讯作者：
De Baets, F.
中科院分区：
文献类型：
--
作者：
Schelstraete, P.;Van daele, S.;De Baets, F.
囊性纤维化患者获得性铜绿假单胞菌的来源尚不清楚。人与人之间的传播已有大量文献，但环境作为初始感染源的作用尚不清楚。在本研究中，通过比较新感染患者的铜绿假单胞菌基因型(S)与家庭环境中分离的铜绿假单胞菌和来自同一CF中心的其他患者的铜绿假单胞菌分离株的基因型别，对首例CF患者铜绿假单胞菌的来源进行了研究。从5.9%的环境样品中可培养出铜绿假单胞菌，对应于18例患者。在其中的9个病例中，环境铜绿假单胞菌的分离株与患者的分离株的基因相同。总体而言，72%的环境铜绿假单胞菌是在浴室中遇到的。不能排除三名患者在CF中心内的患者之间的传播。综上所述，在新感染的囊性纤维化患者的家庭环境中发现铜绿假单胞菌的流行率很低。在任何预防性清洁程序中，卫生间都应该成为目标。在9名患者中，不能排除新感染的环境来源。
The source of acquisition of Pseudomonas aeruginosa in cystic fibrosis (CF) patients remains unknown. Patient-to-patient transmission has been well documented but the role of the environment as a source of initial infection is as yet unclear.In the present study, the origin of the first P. aeruginosa isolate in CF patients was investigated by comparing the P. aeruginosa genotype(s) from newly infected patients with genotypes of P. aeruginosa isolates from the home environment and from other patients from the same CF centre.A total of 50 newly infected patients were studied. P. aeruginosa could be cultured from 5.9% of the environmental samples, corresponding to 18 patients. For nine of these, the genotype of the environmental P. aeruginosa isolate was identical to the patient's isolate. In total, 72% of the environmental P. aeruginosa isolates were encountered in the bathroom. Patient-to-patient transmission within the CF centre could not be ruled out for three patients.In summary, a low prevalence of Pseudomonas aeruginosa was found in the home environment of the newly infected cystic fibrosis patients. The bathroom should be targeted in any preventive cleaning procedures. An environmental source of the new infection could not be ruled out in nine patients.