Antenatal factors and the development of bronchopulmonary dysplasia.
Antenatal factors and the development of bronchopulmonary dysplasia.
复制标题
DOI：
10.1016/s1084-2756(02)00188-4
复制
发表时间：
2003-02-01
期刊：
影响因子：
--
通讯作者：
Jobe, Alan H
中科院分区：
文献类型：
--
作者：
Jobe, Alan H
早产儿的肺经常暴露于产前糖皮质激素，组织学绒毛膜炎是常见的。在临床和实验上，产前糖皮质激素和/或绒毛膜炎与早期肺成熟有关，但在实验模型中，糖皮质激素和子宫内炎症都会减少肺泡化。实验性绒毛膜炎也可以放大早产儿肺对机械通气的炎症反应。在这篇文章中，提出的假设是支气管肺发育不良的发生是因为反复的不良肺暴露或撞击，最初的撞击可能是产前糖皮质激素暴露和/或产前炎症。
The lung of the preterm fetus is often exposed to antenatal glucocorticoids, and histologic chorioamnionitis is frequent. Clinically and experimentally, antenatal glucocorticoids and/or chorioamnionitis are associated with early lung maturation, but in experimental models, both glucocorticoids and intra-uterine inflammation decrease alveolarization. Experimental chorioamnionitis also can amplify the inflammatory response of the preterm lung to mechanical ventilation. In this article, the hypothesis developed is that bronchopulmonary dysplasia occurs because of repetitive adverse lung exposures, or hits, and that the initial hits may be antenatal glucocorticoid exposure and/or antenatal inflammation.