Induction of pancreatic carcinomas in rats with N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine: histopathology.
Induction of pancreatic carcinomas in rats with N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine: histopathology.
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N-亚硝基（2-羟丙基）（2-氧代丙基）胺诱导大鼠胰腺癌：组织病理学。
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
T. Curphey
中科院分区：
文献类型：
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作者：
D. Longnecker;B. Roebuck;E. Kuhlmann;T. Curphey
研究了N-亚硝基(2-羟丙基)(2-氧丙基)胺(HPOP)对大鼠胰腺的致癌性。两周龄雄性LEW大鼠单次ip HPOP，160 mg/kg体重；4、6、12个月后剖检。组织学检查显示胰腺内有多个非典型腺泡细胞结节(AACN)、腺泡细胞腺瘤、局限性癌和癌。癌症发生率为77%。癌由低分化腺泡细胞和导管样结构组成。胰管未受影响。肿瘤的组织学类型、AACN的突出和导管上皮无增生性改变提示胰腺癌起源于腺泡细胞。肝细胞癌和肺腺瘤的发病率与局限性胰腺癌相似。其他器官肿瘤的发生率较低。HPOP已被证明可诱发仓鼠胰腺癌，但此前尚未有报道称HPOP是大鼠胰腺癌的致癌物。
The carcinogenicity of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) for rat pancreas was evaluated. Two-week-old male LEW rats were given a single ip injection of HPOP, 160 mg/kg body weight; the rats were autopsied 4, 6, or 12 months later. Histologic examination showed that the pancreata contained multiple foci of atypical acinar cells and nodules of atypical acinar cells (AACN), acinar cell adenomas, localized carcinomas, and carcinomas. The incidence of carcinomas was 77%. The carcinomas were composed of poorly differentiated acinar cells and ductlike structures. Pancreatic ducts were unaffected. The prominence of AACN, the histologic type of the neoplasms, and the absence of hyperplastic changes in ductal epithelium suggest that the pancreatic carcinomas were derived from acinar cells. The incidence of liver cell carcinomas and pulmonary adenomas was similar to that of localized pancreatic carcinomas. Neoplasms of other organs were less frequent. HPOP has been shown to induce pancreatic carcinomas in hamsters but has not previously been reported to be a pancreatic carcinogen in rats.