Neutrophil to lymphocyte ratio and the hematoma volume and stroke severity in acute intracerebral hemorrhage patients
Neutrophil to lymphocyte ratio and the hematoma volume and stroke severity in acute intracerebral hemorrhage patients
复制标题
急性脑出血患者中性粒细胞与淋巴细胞比值与血肿量及脑卒中严重程度的关系
DOI：
10.1016/j.ajem.2016.11.037
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发表时间：
2017-03-01
影响因子：
3.6
通讯作者：
Liu, Chun-Feng
中科院分区：
文献类型：
--
作者：
Sun, Yaming;You, Shoujiang;Liu, Chun-Feng
背景：中性粒细胞与淋巴细胞比率（NLR）是预测心血管事件的有力炎症标志物。在此，我们调查了急性脑出血（ICH）患者入院后NLR是否与血肿体积、卒中严重程度和3个月预后相关。记录所有参与者的人口统计学特征、生活方式风险因素、NIHSS评分、血肿体积和其他临床特征。根据入院NLR水平将患者分为四分位数（Q1：b2.78; Q2：2.78-4.08; Q3：4.08-7.85; Q4：>= 7.85）。多变量线性回归模型和逻辑回归模型被用来评估NLR与血肿体积、入院严重程度或ICH后结局之间的相关性。中位血肿体积分别为9.5、9.3、9.1和15.0 ml（P =.001）。005），分别。在调整年龄、性别和其他潜在危险因素后，Q4患者的NIHSS评分高于Q4患者（P=. 001）。042)血肿体积较大（P=.014）。3个月随访后，记录了148例不良结局（mRS，3-6）和47例全因死亡。Q4的不良结局患者多于Q1。然而，与Q1的患者相比，Q4的患者与不良结局（P趋势= 0.379）和调整其他危险因素后的全因死亡率（P趋势= 0.843）无关。结论：在急性ICH患者中，较高的入院NLR与较大的血肿体积和更严重的卒中相关，但与3个月的结局无关。(C)2016 Elsevier Inc. All rights reserved.
Background: Neutrophil to lymphocyte ratio (NLR) serves as a powerful inflammatory marker for predicting cardiovascular events. Here, we investigatewhether admission NLR is associatedwith hematoma volume, stroke severity, and 3-month outcomes in patients with acute intracerebral hemorrhage (ICH).Methods: 352 patients with acute ICH were prospectively identified in this study. Demographic characteristics, lifestyle risk factors, NIHSS score, hematoma volumes, and other clinical features were recorded for all participants. Patients was divided into quartiles based on the admission NLR levels (Q1: b2.78; Q2: 2.78-4.08; Q3: 4.08-7.85; Q4: >= 7.85). Multivariable linear regression models and logistic regression models were used to evaluate the association between NLR and hematoma volume, admission severity, or the outcomes after ICH.Results: Median NIHSS scores for each quartile (Q1 to Q4) were 6.0, 6.0, 6.0, and 11.0 (P=. 001), andmedian hematoma volumes were 9.5, 9.3, 9.1, and 15.0 ml (P =. 005), respectively. After adjusting the age, sex, and other potential risk factors, the patients in Q4 had higher NIHSS scores (P=. 042) and larger hematoma volume (P=.014). After 3-month follow-up, 148 poor outcomes (mRS, 3-6) and 47 all-cause deaths were documented. There were more patients with poor outcomes in Q4 than Q1. However, comparedwith the patients in Q1, those in Q4 were not associated with poor outcomes (P-trend= 0.379), and all-cause mortality (P-trend= 0.843) after adjust for other risk factors.Conclusions: Higher admissionNLR are associatedwith larger hematoma volume andmore serious stroke, but not 3-month outcomes in patients with acute ICH. (C) 2016 Elsevier Inc. All rights reserved.