Present status of the total artificial heart at the University of Tokyo.
Present status of the total artificial heart at the University of Tokyo.
复制标题
东京大学全人工心脏的现状。
DOI：
10.1046/j.1525-1594.1999.06325.x
复制
发表时间：
1999
影响因子：
2.4
通讯作者：
K. Imachi
中科院分区：
文献类型：
--
作者：
Y. Abe;T. Chinzei;T. Isoyama;T. Ono;S. Mochizuki;I. Saito;P. Guba;T. Karita;Y. P. Sun;A. Kouno;T. Suzuki;K. Baba;K. Mabuchi;K. Imachi
东京大学自1959年以来一直在研究各种类型的人工心脏(TAH)系统。目前，已开发出两种类型的植入型TAH。一种是波动泵TAH(UPTAH)，另一种是流量变换脉动TAH(FTPTAH)。应用UPTAH在山羊体内进行了14例植入手术，获得了10天的存活。新型FTPTAH正在进行原型研究。为了防止环状血栓，我们研制了一种聚亚安酯膜阀--水母瓣膜。在TAH血泵中使用这种阀门的最长活体经验是在左侧血泵中使用312天，在右侧血泵中使用414天。基于电导和动脉压的控制(1/R控制)可以实现对TAH的生理控制。在1/R对照条件下，患副心型TAH的山羊可存活532天。将这种控制方法应用于植入型TAH所需的技术正在开发中。我们向福利部提出了一项新的5年期可植入TAH研究项目--《日本原创可植入全人工心脏的综合基础研究》。
At the University of Tokyo, various types of total artificial heart (TAH) systems have been studied since 1959. At the present time, 2 types of implantable TAH have been developed. One is an undulation pump TAH (UPTAH) and the other is a flow transformed pulsatile TAH (FTPTAH). Using the UPTAH, 14 cases of implantation were performed in goats and 10 days' survival obtained. The new type of FTPTAH is under a prototype study. To prevent ring thrombus, a polyurethane membrane valve, a jellyfish valve, has been developed. The longest in vivo experiences with this valve in the TAH blood pump have been 312 days in the left side blood pump and 414 days in the right side blood pump. Conductance and arterial pressure based control (1/R control) can realize the physiological control of the TAH. Using 1/R control, 532 days of survival could be obtained in a goat with a paracorporeal TAH. The technique required to apply this control method to a implantable TAH is under development. We have proposed a new 5 year research project of the implantable TAH entitled "Comprehensive Basic Research on the Development of a Japanese Original Implantable Total Artificial Heart" to The Ministry of Welfare.