Magnesium sulfate for acute asthma in adults: a systematic literature review.
Magnesium sulfate for acute asthma in adults: a systematic literature review.
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DOI：
10.5415/apallergy.2012.2.1.76
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发表时间：
2012-01
影响因子：
1.7
通讯作者：
Chang YS
中科院分区：
文献类型：
--
作者：
Song WJ;Chang YS
硫酸镁(MgSO4)被认为是治疗严重和危及生命的哮喘恶化的辅助疗法。应用计算机检索MEDLINE、EMBASE、Cochrane图书馆和Google Scholar数据库，总结镁治疗成人哮喘急性发作期的知识现状。共确定了16项试验和4项荟萃分析。结果表明，静脉注射硫酸镁对重症急性发作是有益的，但雾化吸入镁的证据不足。然而，需要进行更大规模的试验才能对疗效得出确凿的结论。关于安全性问题，文献中所述的通常剂量的主要毒性风险似乎非常低。此外，对4项调查的结果进行了审查，内容涉及知识和实践之间的差距，以及在急诊科使用硫酸镁的障碍。这篇文献综述总结了有关使用硫酸镁治疗急性哮喘的最新证据。我们预计将在亚太地区进行更多的证据研究。
Magnesium sulfate (MgSO4) has been considered as an adjunct therapy for severe and life-threatening asthma exacerbation. The literature search was performed using MEDLINE, EMBASE, Cochrane Library and Google Scholar to summarize the current state of knowledge regarding magnesium therapy in acute exacerbation of adult asthma. A total of 16 trials and 4 meta-analyses were identified. As results, intravenous MgSO4 was beneficial in severe exacerbation, but evidence for nebulized magnesium was insufficient. However, larger trials are required to draw confirmative conclusions on the efficacy. Regarding the safety concern, the risk of major toxicity appears to be very low at usual doses described in the literature. Additionally, results from 4 surveys were examined on the gaps between knowledge and practice, and on the barrier to the use of MgSO4 at emergency departments. This literature review summarized the up-to-date evidence on the issues regarding the use of MgSO4 for acute asthma. We expect more studies to be conducted for evidence making in the Asian-Pacific regions.