Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want.
Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want.
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DOI：
10.1038/s41541-018-0089-x
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发表时间：
2018
期刊：
影响因子：
9.2
通讯作者：
Fox CB
中科院分区：
文献类型：
--
作者：
HogenEsch H;O'Hagan DT;Fox CB
含铝佐剂已被用于增强对疫苗的免疫应答超过90年。最近的工作大大提高了我们对这些佐剂的物理，化学和生物学特性的理解，为潜在机制提供了关键见解。考虑到铝佐剂的长期成功，我们认为它们应该继续代表所有新佐剂应进行比较的“黄金标准”。需要佐剂来诱导保护性免疫应答的新疫苗候选物应首先用铝佐剂进行评估，然后再考虑其他更多的实验方法，因为使用已建立的佐剂将促进临床开发和监管途径。然而，继续使用铝佐剂需要了解其复杂性，并获得必要的专业知识来优化疫苗配方。在这篇文章中，我们将回顾铝佐剂的特性，并强调那些对优化疫苗性能至关重要的元素。我们将讨论其他成分（赋形剂，TLR配体等）可以影响佐剂和抗原之间的相互作用，并影响疫苗的效力。该综述提供了一种资源和指南，最终将有助于成功开发更新、更有效和更安全的疫苗。
Aluminum-containing adjuvants have been used for over 90 years to enhance the immune response to vaccines. Recent work has significantly advanced our understanding of the physical, chemical, and biological properties of these adjuvants, offering key insights on underlying mechanisms. Given the long-term success of aluminum adjuvants, we believe that they should continue to represent the “gold standard” against which all new adjuvants should be compared. New vaccine candidates that require adjuvants to induce a protective immune responses should first be evaluated with aluminum adjuvants before other more experimental approaches are considered, since use of established adjuvants would facilitate both clinical development and the regulatory pathway. However, the continued use of aluminum adjuvants requires an appreciation of their complexities, in combination with access to the necessary expertise to optimize vaccine formulations. In this article, we will review the properties of aluminum adjuvants and highlight those elements that are critical to optimize vaccine performance. We will discuss how other components (excipients, TLR ligands, etc.) can affect the interaction between adjuvants and antigens, and impact the potency of vaccines. This review provides a resource and guide, which will ultimately contribute to the successful development of newer, more effective and safer vaccines.
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