Berry anthocyanins as novel antioxidants in human health and disease prevention
Berry anthocyanins as novel antioxidants in human health and disease prevention
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DOI：
10.1002/mnfr.200700002
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发表时间：
2007-06-01
影响因子：
5.2
通讯作者：
Bagchi, Debasis
中科院分区：
文献类型：
--
作者：
Zafra-Stone, Shirley;Yasmin, Taharat;Bagchi, Debasis
可食用浆果是天然花青素抗氧化剂的潜在来源，具有广泛的生物医学功能。这些包括心血管疾病、年龄增长引起的氧化应激、炎症反应和各种退行性疾病。浆果花青素还可以改善神经元和认知脑功能，眼睛健康以及保护基因组DNA的完整性。本章展示了野生蓝莓，越橘，蔓越莓，接骨木，乌藨子种子和草莓在人类健康和疾病预防方面的有益作用。此外，本章将讨论一种新的组合选择浆果提取物被称为OptiBerry，野生蓝莓，野生越橘，蔓越莓，接骨木莓，树莓种子和草莓的组合，其药理学上的好处，其潜在的好处超过个别浆果。我们实验室最近的研究表明，OptiBerry具有高抗氧化功效，如其高氧自由基吸收能力（ORAC）值所示，新的抗血管生成和抗动脉粥样硬化活性，以及对幽门螺杆菌的潜在细胞毒性，幽门螺杆菌是一种有害病原体，可导致各种胃肠道疾病，包括十二指肠溃疡和胃癌，与单个浆果提取物相比。OptiBerry还显著抑制基础MCP-1和诱导型NF-K β转录因子以及炎症生物标志物IL-8，并显著降低体内模型中形成血管瘤的能力和显著降低EOMA细胞诱导的肿瘤生长。总的来说，浆果花青素触发遗传信号，促进人类健康和疾病预防。
Edible berries, a potential source of natural anthocyanin antioxidants, have demonstrated a broad spectrum of biomedical functions. These include cardiovascular disorders, advancing age-induced oxidative stress, inflammatory responses, and diverse degenerative diseases. Berry anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protect genomic DNA integrity. This chapter demonstrates the beneficial effects of wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry in human health and disease prevention. Furthermore, this chapter will discuss the pharmacological benefits of a novel combination of selected berry extracts known as OptiBerry, a combination of wild blueberry, wild bilberry, cranberry, elderberry, raspberry seeds, and strawberry, and its potential benefit over individual berries. Recent studies in our laboratories have demonstrated that OptiBerry exhibits high antioxidant efficacy as shown by its high oxygen radical absorbance capacity (ORAC) values, novel antiangiogenic and antiatherosclerotic activities, and potential cytotoxicity towards Helicobacter pylori, a noxious pathogen responsible for various gastrointestinal disorders including duodenal ulcer and gastric cancer, as compared to individual berry extracts. OptiBerry also significantly inhibited basal MCP-1 and inducible NF-K beta transcriptions as well as the inflammatory biomarker IL-8, and significantly reduced the ability to form hemangioma and markedly decreased EOMA cell-induced tumor growth in an in vivo model. Overall, berry anthocyanins trigger genetic signaling in promoting human health and disease prevention.