Nicotine treatment produces persistent increases in amphetamine-stimulated locomotor activity in periadolescent male but not female or adult male rats
Nicotine treatment produces persistent increases in amphetamine-stimulated locomotor activity in periadolescent male but not female or adult male rats
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DOI：
10.1016/j.devbrainres.2004.08.004
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发表时间：
2004-11-25
期刊：
影响因子：
--
通讯作者：
Izenwasser, S
中科院分区：
文献类型：
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作者：
Collins, SL;Montano, R;Izenwasser, S
尼古丁是一种在青少年人群中普遍使用的成瘾性药物，长期以来，人们一直质疑青少年使用尼古丁是否会导致使用其他精神兴奋剂药物。然而，尼古丁如何改变青少年群体的行为和脑神经化学，以及这如何影响随后的非法药物使用，目前尚不完全清楚。在本研究中，对青春期和成年雄性和雌性大鼠进行了7天的尼古丁治疗。治疗1天或30天后，研究安非他明对运动活动的影响。在7天的治疗期内，青春期前后雌性大鼠、成年雄性大鼠和雌性大鼠均出现尼古丁致敏，但青春期前后雄性大鼠未出现尼古丁致敏。在第8天（尼古丁治疗结束后1天）和第37天（尼古丁治疗结束后30天），尼古丁预处理的青春期周围雄性大鼠对安非他明的运动激活作用敏感。青春期前后雌性和成年雌雄大鼠对安非他命的反应在尼古丁预处理后的任何时间点都没有变化。因此，青少年男性在接触尼古丁后对安非他命的刺激作用比成年人或女性更敏感，而且这种作用是持久的。这些数据表明，青少年时期使用尼古丁的风险可能比成年时期更大，男性青少年吸烟者可能特别容易受到滥用兴奋剂的风险。(C) 2004 Elsevier B.V.版权所有
Nicotine is a popular addictive drug used among the adolescent population, and it has long been questioned whether nicotine use in adolescence may lead to the use of other psychostimulant drugs. It is not fully understood, however, how nicotine alters behavior and brain neurochemistry in the adolescent age cohort and how this may affect subsequent illicit drug use. In the current study, periadolescent and adult male and female rats were treated with nicotine for 7 days. One day or 30 days after this treatment, the effects of amphetamine on locomotor activity were studied. Sensitization to nicotine occurred in periadolescent female and adult male and female rats, but not in periadolescent male rats over the course of the 7-day treatment period. On day 8 (1 day after treatment with nicotine ended) and on day 37 (30 days after treatment with nicotine ended), nicotine-pretreated periadolescent male rats were sensitized to the locomotor-activating effects of amphetamine. The response to amphetamine of periadolescent female and adult male and female rats was unchanged at either time point after nicotine pretreatment. Thus, adolescent males are more sensitive than adults or females to the stimulant effects of amphetamine after exposure to nicotine, and this effect is long-lasting. These data suggest that nicotine use during adolescence may carry a greater risk than during adulthood and that male adolescent smokers may be particularly vulnerable to the risk of stimulant abuse. (C) 2004 Elsevier B.V. All rights reserved.