Daytime Napping Duration is Positively Associated with Risk of Hyperuricemia in Chinese Population.
Daytime Napping Duration is Positively Associated with Risk of Hyperuricemia in Chinese Population.
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DOI：
10.1210/clinem/dgab043
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发表时间：
2021-01
期刊：
影响因子：
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通讯作者：
Yanjiao Wang;Yongli Zeng;Xuehui Zhang;Qiong Meng;Fei Mi;Songmei Wang;Fang Xu;Yan Sun;
中科院分区：
文献类型：
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作者：
Yanjiao Wang;Yongli Zeng;Xuehui Zhang;Qiong Meng;Fei Mi;Songmei Wang;Fang Xu;Yan Sun;
背景睡眠缺失或睡眠-觉醒周期紊乱与代谢损伤有关。然而，很少有研究调查日常睡眠时间与高尿酸血症之间的关系。目的探讨日常睡眠时间(日间午睡和夜间睡眠)与高尿酸血症的关系。设计背景：对来自云南中国多民族队列的数据进行横断面分析。2018年共招募了22,038名年龄在30岁至79岁之间的受试者。高尿酸血症定义为男性血尿酸(SUA)>7.0 mg/dL，女性>6.0 mg/dL。每天睡眠时间与高尿酸血症之间的结果关联。结果在调整人口学、睡眠习惯和代谢危险因素后，在粗略模型[OR(95%CI)=2.2 2(1.88，2.61)，P<；0.0001]和多变量调整模型[OR：1.69；95%CI：(1.41，2.01)，P<；0.0001]中，白天午睡时间越长，高尿酸血症的风险越高。这种相关性在附加调整了血肌酐的情况下有所减弱[OR：1.54；95%CI：(1.28，1.86)，P<；0.0001]。白天午睡时间较长也与高尿酸血症合并代谢综合征(METS)的风险较高有关。在完全校正模型中，白天小睡时间≥为90min的受试者发生高尿酸血症合并METS的风险较高[OR：1.3 9；95%CI：(1.0 6，1.79)；P<；0.001]。在这项研究中，我们没有观察到夜间睡眠时间与高尿酸血症风险之间的任何关系。结论在中国人群中，白天小睡时间较长(但夜间睡眠时间不长)与高尿酸血症的风险独立相关。
CONTEXT Loss of sleep or disturbance of sleep-wake cycles have been related with metabolic impairments. However, few studies have investigated the association between daily sleep duration and hyperuricemia. OBJECTIVE We investigated daily sleep duration (daytime napping and nocturnal sleep) with hyperuricemia risk. DESIGN SETTING We cross-sectionally analyzed data from the China Multi-Ethnic Cohort (CMEC), Yunnan region. A total of 22,038 subjects aged 30-79 years were recruited in 2018. Hyperuricemia was defined as serum uric acid (SUA) above 7.0 mg/dL in males and above 6.0 mg/dL in females. OUTCOME Associations between daily sleep duration and hyperuricemia. RESULTS We found that the longest daytime napping duration was associated with higher risk of hyperuricemia in the crude model [OR (95%CI) is 2.22 (1.88, 2.61), P < 0.0001] and in a multivariable adjustment model [OR: 1.69; 95%CI: (1.41, 2.01), P < 0.0001] after adjusting for demographic, sleep habits and metabolic risk factors. The association was moderately attenuated with additionally adjusted for serum creatinine [OR: 1.54; 95%CI: (1.28, 1.86), P < 0.0001]. Longer daytime napping duration was also related with higher risk of hyperuricemia combined with metabolic syndrome (MetS). Respondents in the daytime napping duration ≥ 90 min presented higher risk of hyperuricemia combined with MetS [OR: 1.39; 95%CI: (1.06, 1.79); P < 0.001] in fully adjusted model. We did not observe any relation between nocturnal sleep duration and risk of hyperuricemia in the study. CONCLUSIONS Longer daytime napping duration (but not nocturnal sleep duration) was independently associated with risk of hyperuricemia in Chinese population.