A proposal for the physiological significance of mdr1 and Bcrp1/Abcg2 gene expression in normal tissue regeneration and after cancer therapy
A proposal for the physiological significance of mdr1 and Bcrp1/Abcg2 gene expression in normal tissue regeneration and after cancer therapy
复制标题
DOI：
10.1016/j.jtbi.2004.07.018
复制
发表时间：
2005-01-07
影响因子：
2
通讯作者：
Garcia, L
中科院分区：
文献类型：
--
作者：
Israeli, D;Ziaei, S;Garcia, L
细胞多药耐药性（MDR），其通常在经历抗癌治疗的患者的癌细胞中发展，仍然是成功的癌症治疗的显著障碍。细胞MDR发展的主要原因之一是ABC转运蛋白基因如mdr 1和Bcrp 1/Abcg 2的表达增加。尽管经过多年的深入研究，mdr 1在癌症中的天然生物学作用仍然难以捉摸。然而，从观察到P-gp（mdr 1编码的蛋白质）在干细胞中广泛表达以及发现P-gp具有独立于外源性药物应用的抗凋亡活性中，得到了关于这种作用的一些提示。在这里，我们讨论了我们自己和其他小组最近发表的作品，并提出了一个完整的观点，mdr 1和Bcrp 1/Abcg 2活性在组织再生过程中的正常组织作为一个应力诱导的再生遗传程序的一部分，并在癌组织中响应癌症治疗。(C)2004爱思唯尔有限公司保留所有权利。
Cellular multi-drug resistance (MDR), which often develops in cancer cells of patients subjected to anti-cancer treatment, remains a significant barrier to successful cancer therapy. One of the principal causes of cellular MDR development is an increased expression of ABC-transporter genes such as mdr1 and Bcrp1/Abcg2. Despite many years of intensive research, the natural biological role of mdr1 in the context of cancer has remained elusive. Some hints about this role came, however, from an observation that P-gp, the mdr1 encoded protein, is expressed widely in stem cells and from the discovery that P-gp possesses an anti-apoptotic activity independently of exogenous drug application. Here, we discuss our own and other groups' recently published works and propose an integrated view of mdr1 and Bcrp1/Abcg2 activity during tissue regeneration in normal tissues as part of a stress-induced regeneration genetic program and in cancerous tissues in response to cancer therapy. (C) 2004 Elsevier Ltd. All rights reserved.