LONG-TERM RISK-FACTORS FOR DEVELOPING ASTHMA AND ALLERGIC RHINITIS - A 23-YEAR FOLLOW-UP-STUDY OF COLLEGE-STUDENTS
LONG-TERM RISK-FACTORS FOR DEVELOPING ASTHMA AND ALLERGIC RHINITIS - A 23-YEAR FOLLOW-UP-STUDY OF COLLEGE-STUDENTS
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DOI：
10.2500/108854194778816634
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
SETTIPANE, GA
中科院分区：
文献类型：
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作者：
SETTIPANE, RJ;HAGY, GW;SETTIPANE, GA
在23年前的初步研究中，1836名大学新生通过问卷调查、访谈和体检进行了前瞻性评估，包括哮喘、过敏性鼻炎和对花粉、动物提取物和霉菌的过敏皮肤试验阳性。在一项为期23年的随访研究中，1021人（64%）返回了完整的问卷。其中738人（72%）在大一时接受了皮肤测试。这项跟踪研究的结果显示，哮喘和过敏性鼻炎的频率随着年龄的增长而不断增加。过敏性鼻炎和过敏性皮肤试验阳性是发展为新哮喘的重要危险因素。患有这两种疾病的人患哮喘的可能性是阴性对照的三倍。在23年的时间里，患新花粉热的风险是皮试阴性学生的2.3倍。哮喘与过敏相关的比例为61%（51/84）。的哮喘患者过敏原皮试阳性，建议对所有哮喘患者进行过敏原评估，以确定并可能消除哮喘触发源。
In the initial study of 23 years ago, 1836 college freshmen were prospectively evaluated by questionnaires, interviews, and physical examinations for medical conditions which included the presence of asthma, allergic rhinitis, and positive allergy skin tests to a battery of pollens, animal extracts, and mold. In a 23-year follow-up study, 1021 (64%) returned their completed questionnaires. Of these, 738 (72%) had been skin tested as freshmen.The results of this follow-up study revealed that the frequency of asthma and allergic rhinitis continue to increase as the individuals become older. Allergic rhinitis and positive allergy skin tests are significant risk factors for developing new asthma. Individuals with either of these diagnoses are about three times more likely to develop asthma than negative controls.Positive allergy skin tested students have more than twice (2.3x) the risk of developing new hay fever than do negative skin tested students over a 23-year period.Asthma correlated to allergies in that 61% (51/84) of our asthmatic subjects have positive allergy skin tests.It is suggested that all asthmatic patients have an allergy evaluation to identify and possibly remove asthma trigger sources.