Rhythmic activity of feline dorsal and ventral spinocerebellar tract neurons during fictive motor actions
Rhythmic activity of feline dorsal and ventral spinocerebellar tract neurons during fictive motor actions
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DOI：
10.1152/jn.00649.2012
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发表时间：
2013-01-01
影响因子：
2.5
通讯作者：
Hultborn, Hans
中科院分区：
文献类型：
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作者：
Fedirchuk, Brent;Stecina, Katinka;Hultborn, Hans
2005年10月27日，张明，张伟.猫背侧和腹侧脊髓小脑束神经元在虚拟运动动作中的节律活动。J Neurophysiol 109：375-388，2013.首次发表于2012年10月24日; doi：10.1152/jn.00649.2012.-背侧脊髓小脑束（DSCT）的神经元已被描述为在去大脑猫在跑步机上行走时有节奏地活动，但这种活动在后肢去传入后停止。这一观察结果支持了DSCT神经元在运动过程中主要中继后肢传入活动，但缺乏来自脊髓中枢模式发生器的输入的假设。腹侧脊髓小脑束（VSCT）神经元，另一方面，被发现是活跃的实际运动（在跑步机上），甚至在传入神经阻滞后，以及在虚构的运动（无相位传入反馈）。在这项研究中，我们比较了DSCT和VSCT神经元的活动在虚构的节奏运动行为。我们使用去大脑猫的准备，其中虚构的运动任务可以诱发，而动物是瘫痪的，没有节奏的感觉输入从后肢神经。脊髓小脑束细胞与细胞体位于腰段的电生理技术和检查外和细胞内微电极记录。在虚构的运动，57/81 DSCT和30/30 VSCT神经元表现出阶段性，周期相关的活动。在虚拟抓挠过程中，19/29个DSCT神经元显示与抓挠周期相关的活动。我们首次提供证据表明，运动和划痕驱动电位不仅存在于VSCT中，而且存在于大多数DSCT神经元中。这些结果表明，两个脊髓小脑束接收输入的中央模式发生器电路，往往足以引起火灾的感觉输入的情况下。
Fedirchuk B, Stecina K, Kristensen KK, Zhang M, Meehan CF, Bennett DJ, Hultborn H. Rhythmic activity of feline dorsal and ventral spinocerebellar tract neurons during fictive motor actions. J Neurophysiol 109: 375-388, 2013. First published October 24, 2012; doi:10.1152/jn.00649.2012.-Neurons of the dorsal spinocerebellar tracts (DSCT) have been described to be rhythmically active during walking on a treadmill in decerebrate cats, but this activity ceased following deafferentation of the hindlimb. This observation supported the hypothesis that DSCT neurons primarily relay the activity of hindlimb afferents during locomotion, but lack input from the spinal central pattern generator. The ventral spinocerebellar tract (VSCT) neurons, on the other hand, were found to be active during actual locomotion (on a treadmill) even after deafferentation, as well as during fictive locomotion (without phasic afferent feedback). In this study, we compared the activity of DSCT and VSCT neurons during fictive rhythmic motor behaviors. We used decerebrate cat preparations in which fictive motor tasks can be evoked while the animal is paralyzed and there is no rhythmic sensory input from hindlimb nerves. Spinocerebellar tract cells with cell bodies located in the lumbar segments were identified by electrophysiological techniques and examined by extra-and intracellular microelectrode recordings. During fictive locomotion, 57/81 DSCT and 30/30 VSCT neurons showed phasic, cycle-related activity. During fictive scratch, 19/29 DSCT neurons showed activity related to the scratch cycle. We provide evidence for the first time that locomotor and scratch drive potentials are present not only in VSCT, but also in the majority of DSCT neurons. These results demonstrate that both spinocerebellar tracts receive input from the central pattern generator circuitry, often sufficient to elicit firing in the absence of sensory input.