Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications.
Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications.
复制标题
使用常规和非典型抗精神病药物治疗老年人的室性心律失常和脑血管事件。
DOI：
10.1097/jcp.0b013e31815a882b
复制
发表时间：
2007
影响因子：
2.9
通讯作者：
Brookhart,MAlan
中科院分区：
文献类型：
--
作者：
Wang,PhilipS;Schneeweiss,Sebastian;Setoguchi,Soko;Patrick,Amanda;Avorn,Jerry;Mogun,Helen;Choudhry,NiteeshK;Brookhart,MAlan
（Wilks Lambda= 0.59; F15= 3.14； P< 0.0000）。个体方差分析显示，与NNS组相比，QS组和RS组在床上的时间更长，睡眠维持时间减少，睡眠潜伏期延长，醒着时间增加，但总的睡眠时间没有差异。与NNS组相比，QS组和RS组的REM潜伏期轻微增加，REM百分比下降。第2阶段睡眠显著增加，而QS组和RS组的SWS均减少。QS组和RS组在任何视觉睡眠评分方面都没有差异（数据未显示）。个体ANCOVAs在REM和delta计数（总数和平均值）上显示了有趣的组间差异（表1）。事后比较显示，与NNS组相比，QS组的平均快速眼动次数显著增加，但RS组与NNS组没有差异。我们还检查了药物剂量和快速眼动计数之间是否存在剂量效应关系。奎硫平平均剂量为313.33 T 228.71 mg，利培酮平均剂量为3.25 T 2.12 mg。总REM计数（Spearman R= 0.57； P= 0.03）和平均REM计数（>= 0.54；P= 0.046）与喹硫平剂量呈正相关。接受奎硫平和利培酮治疗的患者在睡眠质量方面没有任何差异。匹兹堡睡眠质量量表测量与任何睡眠脑电图测量或药物剂量在两个治疗组中都没有显著相关性。与先前的研究结果一致，1治疗的慢性精神分裂症患者睡眠维持时间减少，睡眠潜伏期和清醒时间增加。与从未接受过治疗的精神分裂症患者相比，他们也有更明显的SWS和REM睡眠减少，但第二阶段的比例更高。因此，在慢性精神分裂症中，睡眠可能更肤浅；这可能会降低睡眠质量，因为睡眠深度和总SWS量已被发现与睡眠质量有关。12
(Wilks Lambda= 0.59; F15= 3.14; P< 0.0000) across the 3 patient groups. Individual analyses of variance revealed that by comparison to the NNS group, both the QS and RS groups had more time in bed, reduced sleep maintenance, prolonged sleep latency, and increased wake time but no difference in total time spent asleep. The REM latency was marginally increased, and REM percentage decreased in the QS and RS groups compared with that in the NNS group. Stage 2 sleep was significantly increased, whereas SWS was decreased in both QS and RS groups. The QS and RS groups did not differ in any visually scored sleep measure (data not shown). Individual ANCOVAs revealed interesting group differences in both REM and delta counts (total and average)(Table 1). Post hoc comparisons revealed that average REM counts were highly significantly elevated in the QS group compared with those in the NNS, but the RS group did not differ from the NNS group. We also examined if a dose-effect relationship exists between medication dose and the REM counts. The mean quetiapine dose was 313.33 T 228.71 mg, and the mean risperidone dose was 3.25 T 2.12 mg. Total (Spearman R= 0.57; P= 0.03) and average REM counts (>= 0.54; P= 0.046) correlated positively with quetiapine dose. None of the sleep quality measures differed between the quetiapine-and risperidone-treated patients. Pittsburgh Sleep Quality Inventory measures did not significantly correlate with any of the sleep electroencephalogram measures or medication dose in either treated group.Consistent with prior findings, 1 treated patients with chronic schizophrenia had reduced sleep maintenance and increases in sleep latency and awake time. They also had more prominent SWS and REM sleep reductions but more stage 2 percentage compared with never-treated schizophrenia subjects. Thus, in chronic schizophrenia, sleep may be more superficial; this may reduce sleep quality because sleep depth and the total SWS amounts have been found to be related to sleep quality. 12
登录
查看更多内容
DOI：
10.1172/jci110967
发表时间：
1983
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Tse,TF;Clutter,WE;Shah,SD;Cryer,PE
通讯作者：
Cryer,PE
胰岛素依赖型糖尿病患者黎明现象发病机制的研究。
DOI：
--
发表时间：
1984
期刊：
Metabolism: Clinical and Experimental
影响因子：
--
作者：
W. Kerner;I. Navascués;A. Torres;E. Pfeiffer
通讯作者：
E. Pfeiffer
生长激素水平升高在调节糖尿病代谢紊乱中的重要性。
DOI：
10.1056/nejm198403293101302
发表时间：
1984
期刊：
The New England journal of medicine
影响因子：
--
作者：
Press,M;Tamborlane,WV;Sherwin,RS
通讯作者：
Sherwin,RS
血浆胰高血糖素的异质性。
影响因子：
15.9
作者：
S. Kuku;J. Jaspan;D. Emmanouel;A. Zeidler;A. Katz;A. Rubenstein
通讯作者：
A. Rubenstein
生长抑素的超活性环状六肽类似物。
DOI：
--
发表时间：
1984
期刊：
Life Science
影响因子：
--
作者：
Daniel F. Veber;R. Saperstein;R. Nutt;R. Freidinger;Stephen F. Brady;Paul Curley;D. Perlow;W. J. Paleveda;Christiane D. Colton;A. Zacchei;Dominick J. Tocco;Dale R. Hoff;Richard L. Vandlen;John E. Gerich;Larry Hall;Lawrence J. Mandarino;Eugene H. Cordes;P. Anderson;Ralph Hirschmann
通讯作者：
Ralph Hirschmann