Direct and passive prenatal nicotine exposure and the development of externalizing psychopathology
Direct and passive prenatal nicotine exposure and the development of externalizing psychopathology
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DOI：
10.1007/s10578-007-0059-4
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发表时间：
2007-12-01
影响因子：
2.9
通讯作者：
Beauchaine, Theodore P.
中科院分区：
文献类型：
--
作者：
Gatzke-Kopp, Lisa M.;Beauchaine, Theodore P.
母亲在怀孕期间吸烟与儿童反社会后果之间的关联已经在各种结果中反复证明。然而，关于这种关联是否反映了尼古丁对胎儿大脑发育的直接编程效应，或者是母亲传给孩子的遗传易感性的表型指标，仍有争议。在目前的研究中，我们在133名妇女及其7-15岁的孩子中研究了母亲吸烟与儿童行为之间的关系，这些妇女被招募进行临床精神病理学水平的研究。为了解开母亲吸烟的相关性，将怀孕期间吸烟的妇女与（a）不吸烟的妇女和（B）不吸烟但经历了大量二手接触的妇女进行了比较。二手接触与参与者母亲后代的外在精神病理学增加有关。此外，回归分析表明，吸烟在怀孕期间预测的行为障碍症状，以上的影响，收入，父母的反社会倾向，早产，出生体重，和不良的养育方式。这是第一项扩展暴露于二手烟的外部脆弱性研究结果的研究。
The association between maternal smoking during pregnancy and childhood antisocial outcomes has been demonstrated repeatedly across a variety of outcomes. Yet debate continues as to whether this association reflects a direct programming effect of nicotine on fetal brain development, or a phenotypic indicator of heritable liability passed from mother to child. In the current study, we examine relations between maternal smoking and child behavior among 133 women and their 7-15-year-olds, who were recruited for clinical levels of psychopathology. In order to disentangle correlates of maternal smoking, women who smoked during pregnancy were compared with (a) those who did not smoke, and (b) those who did not smoke but experienced significant second-hand exposure. Second-hand exposure was associated with increased externalizing psychopathology in participant mothers' offspring. Moreover, regression analyses indicated that smoke exposure during pregnancy predicted conduct disorder symptoms, over and above the effects of income, parental antisocial tendencies, prematurity, birth weight, and poor parenting practices. This is the first study to extend the findings of externalizing vulnerability to second hand smoke exposure.