Improved hepatic function in the 24-hour preserved rat liver with UW-lactobionate solution and SRI 63-441.
Improved hepatic function in the 24-hour preserved rat liver with UW-lactobionate solution and SRI 63-441.
复制标题
使用 UW-乳糖酸盐溶液和 SRI 63-441 改善 24 小时保存的大鼠肝脏的肝功能。
DOI：
10.1016/s0016-5085(88)80086-6
复制
发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Starzl,TE
中科院分区：
文献类型：
--
作者：
Ontell,SJ;Makowka,L;Ove,P;Starzl,TE
The present study compares rat liver preservation for 9, 12, and 24 h in the standard Eurocollins solution with preservation for the same time periods in the new UW-Iactobionate solution. Pharmacologic manipulation with a potent plateletactivating factor antagonist, SRI 63-441, was also evaluated. After cold storage in each of the test solutions, the livers underwent 90 min of warm, oxygenated, sanguinous perfusion. A significant increase in liver weight was noted in Eurocollinsstored versus UW-Iactobionate-stored livers. After 90 min of perfusion, livers preserved in UW-lactobionate produced significantly more bile and liberated significantly less glucose and transaminases when compared with Eurocollins-stored livers. Significant augmentation of bile production was observed when donor animals were pretreated with SRI 63-441 and the livers were then stored in UW-lactobionate for 24 h. Eurocollins-stored livers demonstrated increased hepatocyte vacuolization and endothelial disruption when compared with UW-lactobionate-stored livers after 12 and 24 h of preservation. This study demonstrates the superiority of UW-lactobionate solution in liver preservation and suggests that SRI 63-441 may be beneficial in the further reduction of cold ischemic injury.
