Enantiomeric difference in percutaneous penetration of propranolol through rat excised skin.
Enantiomeric difference in percutaneous penetration of propranolol through rat excised skin.
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DOI：
10.1248/cpb.40.1075
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发表时间：
1992-04
影响因子：
1.7
通讯作者：
K. Miyazaki;F. Kaiho;A. Inagaki;M. Dohi;N. Hazemoto;M. Haga;H. Hara;Y. Kato
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文献类型：
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作者：
K. Miyazaki;F. Kaiho;A. Inagaki;M. Dohi;N. Hazemoto;M. Haga;H. Hara;Y. Kato
用离体大鼠离体皮肤研究了R-（+）-和S-（-）-普萘洛尔（PL）的经皮渗透性。与R-（+）-PL相比，S-（-）-PL应用于正常皮肤后的通量较高。另一方面，在损伤的大鼠皮肤中，R-（+）-PL的通量几乎与S-（-）-PL的通量相当。结果表明，S-（-）-和R-（+）-PL在大鼠角质层渗透方面存在对映体差异。
The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro. The flux of S-(-)-PL after application to normal skin was high compared with that of R-(+)-PL. On the other hand, in damaged rat skin, the flux of R-(+)-PL was almost equivalent to that of S-(-)-PL. It is suggested that there is an enantiomeric difference between S-(-)- and R-(+)-PL in terms of penetration through rat stratum corneum.