The effect of race and gender on patterns of rt-PA use within a population.
The effect of race and gender on patterns of rt-PA use within a population.
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种族和性别对人群中 rt-PA 使用模式的影响。
DOI：
10.1016/j.jstrokecerebrovasdis.2003.09.001
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Broderick,JosephP
中科院分区：
文献类型：
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作者：
Kleindorfer,Dawn;Schneider,Alexander;Kissela,BrettM;Woo,Daniel;Khoury,Jane;Alwell,Kathleen;Miller,Rosemary;Gebel,James;Szaflarski,Jerzy;Pancioli,Arthur;Jauch,Edward;Moomaw,Charles;Shukla,Rakesh;Broderick,JosephP
迄今为止，尚未发表关于患者人口统计学因素对rt-PA使用影响的基于人群的数据。我们提供了关于种族和性别对FDA批准前rt-PA使用模式的影响的初步数据，在人口统计学和社会经济学特征与美国相似的人群中。通过审查1993年7月至1994年6月该地区所有医院的所有一级和二级医院ICD-9-CM代码430-438，确定了130万birthday人群中的所有缺血性卒中。作为设盲NINDS rt-PA试验的一部分，记录并分析接受rt-PA或安慰剂治疗的患者数量以及人口统计学特征。在参与NINDS rt-PA试验的医院中，共发生了1973例住院缺血性卒中。接受rt-PA治疗的患者明显比未接受rt-PA治疗的患者年轻（平均年龄分别为67 v72，P = 0.01）。在非裔美国人中发生的413例卒中中，2.2%接受了rt-PA治疗，而1560例非裔美国人中为2.6%。女性（2.0%）和男性（3.0%）接受rt-PA的可能性相同。单个学术中心与社区医疗中心一样可能给予rt-PA。在大辛辛那提/北方肯塔基州人群中，1993-94年rt-PA的使用模式似乎并不因种族或性别或医疗中心类型而异。这些发现可能部分是因为该地区基于区域的中风护理提供方法。
To date, there have been no population-based data published regarding the influence of the patient’s demographic factors on rt-PA use. We present preliminary data regarding the effect of race and gender on patterns of rt-PA use in the pre-FDA approval era, in a population with demographic and socioeconomic characteristics similar to the United States. All ischemic strokes within a biracial population of 1.3 million were identified by review of all primary and secondary hospital ICD-9-CM codes 430–438 from July 1993 to June 1994 at all hospitals in the region. The number of patients treated with rt-PA or placebo as part of the blinded NINDS rt-PA trial, as well as demographic characteristics, were recorded and analyzed. There were a total of 1973 hospitalized ischemic strokes that occurred at a hospital participating in the NINDS rt-PA trial. Patients that received rt-PA were significantly younger than those that did not (mean age 67 v 72, respectively, P = .01). Of the 413 strokes that occurred in African Americans, 2.2% were treated with rt-PA vs. 2.6% of the 1560 non-African Americans. Women (2.0%) and men (3.0%) were equally likely to receive rt-PA. The single academic center was as likely to give rt-PA as the community medical centers. In the Greater Cincinnati/Northern Kentucky population, patterns of rt-PA use in 1993–94 did not appear to vary according to race or gender, or type of medical center. These findings may be in part because of the regionally-based method of stroke care delivery in the area.