Effect of gender on thermoregulation and survival of hypoxic rats.
Effect of gender on thermoregulation and survival of hypoxic rats.
复制标题
性别对缺氧大鼠体温调节和生存的影响。
DOI：
10.1111/j.1440-1681.1998.tb02196.x
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发表时间：
1998
影响因子：
2.9
通讯作者：
Stabenau,EK
中科院分区：
文献类型：
--
作者：
Wood,SC;Stabenau,EK
1. 体温过低是对缺氧的一种有记录的反应，但对可能的性别差异知之甚少。由于雌性大鼠比雄性有更大的缺氧通气反应，我们假设雌性对缺氧的耐受性更强。我们研究了18只雌性和18只雄性Long - Evans大鼠。2 .全身麻醉（氯胺酮90 mg/mL、噻嗪10 mg/mL； 0.1 mL/100 g体重，i.p.）下植入体温无线遥测发射机（Tb）。将大鼠分别暴露于21、16、12、10、8、6、4和2%的O2（平衡N2）中，分别在31°C（夹住）或20°C（低温）的环境中30分钟。生存被定义为共济失调和无反应。女性比男性更耐缺氧，经常承受2%的吸入O2（13 km海拔）。这与低温组较低的Tb相关，但与夹紧组无关。低温增加了与性别无关的大鼠的“存活率”。当夹住结核时，雌性大鼠的存活率明显高于雄性大鼠。因此，不同的机制（低温或通气）可能会增加夹住和低温的雌性大鼠对严重缺氧的耐受性。
1. Hypothermia is a documented response to hypoxia but little is known about possible gender differences. Because female rats have a greater hypoxic ventilatory response than males, we hypothesized that females would be more tolerant of hypoxia. We studied 18 female and 18 male Long‐Evans rats.2. Radiotelemetry transmitters for body temperature (Tb) were implanted under general anaesthesia (90 mg/mL ketamine and 10 mg/mL xylazine; 0.1 mL/100 g body weight, i.p.).3. Rats were exposed to 21, 16, 12, 10, 8, 6, 4 and 2% O2(balance N2) for 30 min each in chambers kept at either 31°C (clamped) or 20°C (hypothermic). Survival was defined as ataxic and unresponsive.4. Females were more hypoxia tolerant than males, often enduring 2% inspired O2(13 km altitude).5. This was correlated with a lower Tb in the hypothermic group, but not in the clamped group.6. Hypothermia increased ‘survival’ of rats independent of gender.7. When Tb was clamped, female rats showed significantly greater survival than males.8. Thus, separate mechanisms (hypothermia or ventilation) may be acting to increase tolerance of clamped and hypothermic female rats to severe hypoxia.