The effects of shifting sleep two hours within a fixed photoperiod.
The effects of shifting sleep two hours within a fixed photoperiod.
复制标题
在固定光周期内改变睡眠两小时的影响。
DOI：
10.1007/bf01244658
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Singer,CM
中科院分区：
文献类型：
--
作者：
Hoban,TM;Lewy,AJ;Sack,RL;Singer,CM
本研究考察了在一个恒定的光周期内改变睡眠时间对体温昼夜节律和褪黑激素分泌的影响。受试者在长时间（从下午6点到早上8点少于10勒克斯的昏暗光线下）生活了三周。为了描绘黎明和黄昏，受试者在时间段前后（即上午8点至9点和下午5点至6点）分别接受1小时的强光照射（2500勒克斯）。在实验的第一周，他们从晚上10点睡到早上6点。在第二周，睡眠时间提前了两个小时；也就是说，受试者在晚上8点就寝，凌晨4点起床。第三周是第一周的重复，导致从第二周到第三周的睡眠延迟了两个小时。成功完成该方案的6名受试者在体温最低和褪黑激素分泌的时间上没有明显变化。这表明，与外部光暗循环的时间相比，允许睡眠的时间对昼夜节律的直接影响较小。睡眠时间的昼夜节律效应可能更多地是由于睡眠-觉醒周期所施加的光-暗周期，而不是睡眠时间本身。
This study examined the effects of shifting the time of sleep within a constant photoperiod on the circadian rhythms of body temperature and melatonin secretion. Subjects lived under conditions of a long scotoperiod (dim light of less than 10 lux from 6 p.m. until 8 a.m.) for three weeks. In order to delineate dawn and dusk, subjects received one hour of bright light (2500 lux) before and after the scotoperiod (i.e., from 8 to 9 a.m. and from 5 to 6 p.m.). For the first week of the experiment they slept from 10 p.m. until 6 a.m. In the second week, sleep was advanced two hours; that is, subjects retired at 8 p.m. and arose at 4 a.m. The third week was a repeat of the first, resulting in a two-hour delay of sleep from week two to three. The six subjects who successfully completed this protocol had no significant changes in the timing of the body temperature minima and onset of secretion of melatonin. This indicates that the timing of allowed sleep has less of an immediate effect on circadian rhythms than the timing of the external light-dark cycle. The circadian effects of the timing of sleep may be due more to the light-dark cycle that is imposed by the sleep-wake cycle than from the timing of sleep itself.