From biophysics to evolutionary genetics: statistical aspects of gene regulation.
From biophysics to evolutionary genetics: statistical aspects of gene regulation.
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DOI：
10.1186/1471-2105-8-s6-s7
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发表时间：
2007-09-27
影响因子：
3
通讯作者：
Lässig M
中科院分区：
文献类型：
--
作者：
Lässig M
这是一个介绍性的审查如何基因相互作用，以产生生物功能。转录相互作用涉及蛋白质与调控DNA的结合。特异性结合位点可以通过基因组分析来鉴定，并且这些位点经历由选择、突变和遗传漂变控制的随机进化过程。我们专注于生物物理功能和调控元件的进化之间的联系。特别是，我们从基因组数据中推断结合位点的适应性景观，从而得出调控的定量进化图。
This is an introductory review on how genes interact to produce biological functions. Transcriptional interactions involve the binding of proteins to regulatory DNA. Specific binding sites can be identified by genomic analysis, and these undergo a stochastic evolution process governed by selection, mutations, and genetic drift. We focus on the links between the biophysical function and the evolution of regulatory elements. In particular, we infer fitness landscapes of binding sites from genomic data, leading to a quantitative evolutionary picture of regulation.