Sleep and biomarkers in the English Longitudinal Study of Ageing: Associations with C-reactive protein, fibrinogen, dehydroepiandrosterone sulfate and hemoglobin
Sleep and biomarkers in the English Longitudinal Study of Ageing: Associations with C-reactive protein, fibrinogen, dehydroepiandrosterone sulfate and hemoglobin
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DOI：
10.1016/j.psyneuen.2012.12.015
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发表时间：
2013-09-01
影响因子：
3.7
通讯作者：
Steptoe, Andrew
中科院分区：
文献类型：
--
作者：
Jackowska, Marta;Kumari, Meena;Steptoe, Andrew
睡眠时间和质量与不良的身体健康结果有关。其机制尚不清楚，并且对老年人群中生物标志物的相关性知之甚少。这项研究评估了50岁及以上英国人的代表性样本中自我报告的睡眠测量和生物标志物之间的横截面关联。参与者是来自英国老龄化纵向研究（艾尔莎）的6465名50-99岁的男性和女性。分析了睡眠持续时间和睡眠障碍与C反应蛋白（CRP）、纤维蛋白原、硫酸脱氢表雄酮（DHEAS）和血红蛋白的关系，调整了年龄、财富、体重指数（BMI）、吸烟、体力活动、限制长期疾病和抑郁症状。男性睡眠时间长（OR：1.50，1.05-2.14）和睡眠障碍（OR：1.29，C. I. 1.05-1.59）与CRP水平升高相关，而长时间睡眠也与血浆纤维蛋白原升高相关（P = 0.001）。报告睡眠障碍较多的男性的DHEAS水平较低（P = 0.016），但与睡眠时间无关。睡眠持续时间（P = 0.015）和睡眠障碍（P = 0.039）与较低的血红蛋白水平相关，贫血在睡眠障碍的男性中更普遍（OR：1.73，C.I. 1.13-2.65）。在女性中，更受干扰的陡峭与更大的贫血可能性相关（OR：1.59，C.I. 1.02-2.46），但睡眠障碍或持续时间与其他生物标志物之间没有关系。这项研究表明，自我报告的睡眠时间和干扰与社区居住的老年人的生物风险因素有关，男性和女性存在不同的关联。使用纵向队列研究更好地理解这些关系将拓宽我们对睡眠指数与老年健康状况不佳相关机制的理解。皇冠版权所有（C）2013由爱思唯尔有限公司出版。保留所有权利。
Sleep duration and quality are associated with adverse physical health outcomes. The mechanisms are not well understood, and little is known about associations with biomarkers in older population cohorts. This study assessed cross-sectional associations between self-reported sleep measures and biomarkers in a representative sample of British people aged 50 years and above. Participants were 6465 men and women aged 50-99 years from the English Longitudinal Study of Ageing (ELSA). Associations of sleep duration and sleep disturbance with C-reactive protein (CRP), fibrinogen, dehydroepiandrosterone sulfate (DHEAS) and hemoglobin were analyzed, adjusting for age, wealth, body mass index (BMI), smoking, physical activity, limiting long-standing illness and depressive symptoms. In men, long sleep duration (OR: 1.50, 1.05-2.14) and greater sleep disturbance (OR: 1.29, C. I. 1.05-1.59) were associated with raised CRP levels, while long sleep was also related to raised plasma fibrinogen (P = 0.001). DHEAS levels were lower among men reporting more sleep disturbances (P = 0.016), but were not related to sleep duration. Sleep duration (P = 0.015) and sleep disturbance (P = 0.039) were associated with lower hemoglobin levels, and anemia was more prevalent among men with disturbed sleep (OR: 1.73, C.I. 1.13-2.65). In women more disturbed steep was associated with greater likelihood of anemia (OR: 1.59, C.I. 1.02-2.46), but there was no relationship between sleep disturbance or duration with other biomarkers. This study suggests that self-reported sleep duration and disturbance are related to biological risk factors in community-dwelling older adults, with different associations being present in men and women. A better understanding of these relationships using longitudinal cohort studies will broaden our understanding of the mechanisms relating sleep indices and ill health in advancing age. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.