Integrating Brain and Behavior: Evaluating Adolescents' Response to a Cannabis Intervention
Integrating Brain and Behavior: Evaluating Adolescents' Response to a Cannabis Intervention
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DOI：
10.1037/a0029767
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发表时间：
2013-06-01
影响因子：
3.4
通讯作者：
Filbey, Francesca M.
中科院分区：
文献类型：
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作者：
Ewing, Sarah W. Feldstein;McEachern, Amber D.;Filbey, Francesca M.
客户语言(改变谈话[CT]和反改变谈话[CCT])作为心理社会干预的一个积极因素，正获得越来越多的支持。对成年人的初步研究表明，这可能是有神经基础的。通过对青少年吸食大麻者的不同样本，我们评估了CT和CCT在功能磁共振大麻线索暴露范例中对血氧水平依赖(BOLD)反应的影响。我们还调查了大胆激活与治疗结果的关系。青少年大麻吸毒者(N=43；83.7%男性；53.5%西班牙裔；男性年龄=16岁)在功能磁共振成像范式中接受了扫描前干预过程中的CT和CCT。此外，CT期间的大胆激活(与CCT相比)被测试为1个月后大麻使用行为(大麻使用频率、大麻问题、大麻依赖)的预测因子。我们观察到了一种显著的相互作用，在吸食大麻(但不是对照)线索期间，CT(与CCT相比)在几个自我参照过程的关键区域(未纠正的P<；0.001；额叶内侧回，脑岛)有更大的激活。此外，在吸食大麻期间(但不是对照)，在内省(后扣带回、楔前核)区域的CT(与CCT)期间的大胆激活与青少年1个月的随访大麻使用行为(使用大麻的频率、大麻问题、大麻依赖；未纠正的P
Client language (change talk [CT] and counterchange talk [CCT]) is gaining increasing support as an active ingredient of psychosocial interventions. Preliminary work with adults suggests that there may be a neural basis for this. With a diverse sample of adolescent cannabis users, we evaluated the influence of CT and CCT on blood oxygen level dependent (BOLD) response during an fMRI cannabis cue-exposure paradigm. We also investigated how BOLD activation related to treatment outcomes. Adolescent cannabis users (N = 43; 83.7% male; 53.5% Hispanic; M age = 16 years) were presented with CT and CCT derived from their prescan intervention session during the fMRI paradigm. Additionally, BOLD activation during CT (vs. CCT) was tested as a predictor of 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence). We observed a significant interaction, with greater activation during CT (vs. CCT) during the cannabis (but not control) cues in several areas key to self-referential processes (uncorrected p < 0.001; medial frontal gyms, insula). Furthermore, BOLD activation during CT (vs. CCT) during cannabis (but not control) cues in areas that underlie introspection (posterior cingulate, precuneus) was significantly related to youths' 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence; uncorrected p