Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart.
Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart.
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DOI：
10.3390/biom13091409
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发表时间：
2023-09-19
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
Heart failure is a serious global health challenge, affecting more than 6.2 million people in the United States and is projected to reach over 8 million by 2030. Independent of etiology, failing hearts share common features, including defective calcium (Ca2+) handling, mitochondrial Ca2+ overload, and oxidative stress. In cardiomyocytes, Ca2+ not only regulates excitation–contraction coupling, but also mitochondrial metabolism and oxidative stress signaling, thereby controlling the function and actual destiny of the cell. Understanding the mechanisms of mitochondrial Ca2+ uptake and the molecular pathways involved in the regulation of increased mitochondrial Ca2+ influx is an ongoing challenge in order to identify novel therapeutic targets to alleviate the burden of heart failure. In this review, we discuss the mechanisms underlying altered mitochondrial Ca2+ handling in heart failure and the potential therapeutic strategies.
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DOI：
10.3390/antiox9090860
发表时间：
2020-09-14
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Bode D;Wen Y;Hegemann N;Primessnig U;Parwani A;Boldt LH;M Pieske B;R Heinzel F;Hohendanner F
通讯作者：
Hohendanner F
影响因子：
4
作者：
Austin S;Tavakoli M;Pfeiffer C;Seifert J;Mattarei A;De Stefani D;Zoratti M;Nowikovsky K
通讯作者：
Nowikovsky K
DOI：
10.1073/pnas.0501961102
发表时间：
2005-07-26
影响因子：
11.1
作者：
Beaumont, V;Llobet, A;Lagnado, L
通讯作者：
Lagnado, L
影响因子：
4.8
作者：
Aracena-Parks, Paula;Goonasekera, Sanjeewa A.;Hamilton, Susan L.
通讯作者：
Hamilton, Susan L.
影响因子：
4.1
作者：
Bannister, Mark L.;Hamada, Tomoyo;Ikemoto, Noriaki
通讯作者：
Ikemoto, Noriaki