CS+ CAUSES A VOLTAGE-DEPENDENT BLOCK OF INWARD K-CURRENTS IN RESTING SKELETAL-MUSCLE FIBERS
CS+ CAUSES A VOLTAGE-DEPENDENT BLOCK OF INWARD K-CURRENTS IN RESTING SKELETAL-MUSCLE FIBERS
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DOI：
10.1038/267169a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
STANFIELD, PR
中科院分区：
文献类型：
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作者：
GAY, LA;STANFIELD, PR
当青蛙骨骼肌纤维浸泡在含有1：4,000的Cs+和K+的溶液中时，可以观察到通过静息膜的内向K电流的大小减少。这种效果是增强的超极化或外部Cs+浓度的增加。从这些发现可以预测，在Cs+存在下，通过电流电极超极化的纤维中应该可以获得膜电位的再生变化。本报告最后一部分介绍了这些应对措施。在鱿鱼轴突和青蛙node 1，2，内部Cs+产生的延迟，外向K电流的电压依赖性块，虽然这种效果所需的Cs+ K+的比例是远远大于在这里报道的实验中使用。我们的研究结果和最近报道的海星卵细胞中的内向K电流之间可以画出一个更接近的平行。
WHEN frog skeletal muscle fibres are bathed in solutions containing Cs+and K+in the ratio 1 : 4,000, a reduction is observed in the size of inward K currents through the resting membrane. This effect is enhanced by an increase in either hyperpolarisation or external Cs+concentration. It can be predicted from these findings that regenerative changes in membrane potential should be obtainable in fibres, in the presence of Cs+, that are hyperpolarised by means of a current electrode. Such responses are described in the last part of this report. In squid axon and frog node1,2, internal Cs+produces a voltage-dependent block of the delayed, outward K currents, though the ratio of Cs+to K+required for this effect is far greater than that used in the experiments reported here. A closer parallel can be drawn between our findings and those recently reported on the inward K currents in the starfish egg cell3.