Exaggerated response to isotonic saline loading in genetically hypertension-prone rats.
Exaggerated response to isotonic saline loading in genetically hypertension-prone rats.
复制标题
遗传性高血压大鼠对等渗盐水负荷的过度反应。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
L. Dahl
中科院分区：
文献类型：
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作者：
D. Ben;K. Knudsen;L. Dahl
摘要 比较了两种遗传上对高血压具有相反易感性的大鼠对急性口服盐负荷的利尿和利尿钠反应。 Brookhaven R和S品系的成年雌性大鼠被给予6ml。胃内负荷0.6M； 0.3M；和 0.15M 氯化钠溶液。高渗盐水负荷在高血压倾向（S）和高血压抵抗（R）大鼠中引起同等的利尿和钠尿反应。对高渗盐水的利尿反应的特点是两种菌株的尿液渗透压较低但相当：S：758±34； R：779 ± 34 毫渗透压； （p > 0.1）。等渗负荷在 S 组大鼠中产生的利尿和利尿钠反应显着高于 R 组大鼠：V（毫升/2 小时）：2.3 ± 0.7 与 0.8 ± 0.4 (p < 0.1)。数据表明，异常的浓缩机制在等渗容量扩张期间被揭露，而在高渗盐水利尿期间未观察到。在血压正常但有高血压倾向的年轻大鼠中，钠和水的排泄增加表明这种异常先于血压升高的出现。
Abstract The diuretic and natriuretic responses to acute oral salt loads were compared in two strains of rats with genetically determined opposite susceptibility to hypertension. Adult female rats of the Brookhaven R and S strains were given 6 ml. intragastric loads of 0.6M; 0.3M; and 0.15M NaCl solutions. Hypertonic saline loads elicited equivalent diuretic and natriuretic responses in both the hypertension-prone (S) and the hypertension-resistant (R) rats. The diuretic response to hypertonic saline was characterized by low but comparable urine osmolalities in both strains: S: 758 ± 34; R: 779 ± 34 mOsm.; (p > 0.1). Isotonic loads produced a significantly higher diuretic and natriuretic response in the S than in the R rats: V(milliliters per 2 hours): 2.3 ± 0.7 vs. 0.8 ± 0.4 (p 0.1). The data suggest an abnormal concentrating mechanism which is unmasked during isotonic volume expansion and was not observed during hypertonic saline diuresis. The occurrence of an increased sodium and water excretion in young normotensive, but hypertension-prone rats, suggests that the anomaly precedes the advent of elevated blood pressure.