Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome.
Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome.
复制标题
慢性疲劳综合征患者体内针对人类疱疹病毒 6 早期抗原 (p41/38) 的 IgM 抗体的流行情况。
DOI：
10.1093/infdis/172.5.1364
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Peter,JB
中科院分区：
文献类型：
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作者：
Patnaik,M;Komaroff,AL;Conley,E;Ojo-Amaize,EA;Peter,JB
为了评估人类疱疹病毒6型（HHV-6）和慢性疲劳综合征（CFS）之间的关联，使用EIA比较了两组不同地理位置的CFS患者（分别为125例和29例）和健康对照组（分别为150例和15例）的HHV-6早期抗原p41/38（EA）抗体。CFS患者HHV 6 EA IgM阳性率为60%（93/154），IgG阳性率为40%（61/154），两者均阳性率为23%（35/154）。CFS患者中119例（77%）HHV-6 EA IgG或IgM（或两者）阳性;对照组中仅12%（20/165）HHV-6 EA IgG或IgM阳性。这些数据表明，CFS患者比对照组有更多的HHV-6 EA特异性IgM水平升高，可能表明CFS中HHV-6的活跃复制。
To evaluate the association between human herpesvirus 6 (HHV-6) and chronic fatigue syndrome (CFS), 2 geographically separate groups of CFS patients (125 and 29 patients, respectively) and healthy controls (150 and 15 controls, respectively) were compared, using an EIA, for antibodies to HHV-6 early antigen p41/38 (EA). Sixty percent (93/154) of CFS patients were positive for HHV6 EA IgM, 40% (61/154) were positive for IgG, and 23% (35/154) were positive for both. A total of 119 (77%) of the CFS patients were positive for HHV-6 EA IgG or IgM (or both); only 12% (20/ 165)of the controls had IgG or IgM to HHV-6 EA. These data demonstrate that more CFS patients than controls had elevated levels of HHV-6 EA-specific IgM, perhaps indicating active replication of HHV-6 in CFS.