Blunted cardiovascular reactivity relates to depression, obesity, and self-reported health
Blunted cardiovascular reactivity relates to depression, obesity, and self-reported health
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DOI：
10.1016/j.biopsycho.2010.03.016
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发表时间：
2011-02-01
影响因子：
2.6
通讯作者：
Phillips, Anna C.
中科院分区：
文献类型：
--
作者：
Phillips, Anna C.
反应性假说暗示在高血压和其他心血管疾病结果的发展中对急性心理应激的夸大的心血管反应。然而，心血管反应性也被认为是各种心理和行为风险因素与心血管疾病之间的中介。苏格兰西部20 -07研究的各种分析数据一起讨论，并警告过度拉伸原来的反应性假设。血压和心率分别在休息时和急性心算压力任务期间进行评估。首先，抑郁，虽然是心血管疾病的一个假定的危险因素，但似乎并没有通过夸大的反应性来赋予这种风险，因为它与反应性呈负相关。其次，肥胖，另一个危险因素，也与迟钝而不是高度反应有关。最后，较低的反应性与自我报告的健康状况较差有关。类似的关联出现在横断面和前瞻性分析中。这些看似矛盾的结果从反应性假设的含义方面进行了讨论。(C)2010 Elsevier B. V.保留所有权利。
The reactivity hypothesis implicates exaggerated cardiovascular reactions to acute psychological stress in the development of hypertension and other cardiovascular disease outcomes. However, cardiovascular reactivity has also been suggested as a mediator between a variety of psychosocial and behavioural risk factors and cardiovascular disease. Data from various analyses of the West of Scotland Twenty-07 study are discussed together, and caution against over-stretching the original reactivity hypothesis. Blood pressure and heart rate were assessed at rest and during an acute mental arithmetic stress task. First, depression, though a putative risk factor for cardiovascular disease, does not appear to confer this risk via exaggerated reactivity, as it was negatively related to reactivity. Second, obesity, another risk factor, was also associated with blunted rather than heightened reactivity. Finally, lower reactivity was related to poorer self-reported health. Similar associations emerged from both cross-sectional and prospective analyses. These seemingly paradoxical results are discussed in terms of implications for the reactivity hypothesis. (C) 2010 Elsevier B.V. All rights reserved.