Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics.
Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics.
复制标题
灵活的近场无线光电子学作为皮下植入物在光遗传学中的广泛应用
DOI：
10.1016/j.neuron.2016.12.031
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发表时间：
2017-02-08
期刊：
影响因子：
16.2
通讯作者：
Rogers JA
中科院分区：
文献类型：
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作者：
Shin G;Gomez AM;Al-Hasani R;Jeong YR;Kim J;Xie Z;Banks A;Lee SM;Han SY;Yoo CJ;Lee JL;Lee SH;Kurniawan J;Tureb J;Guo Z;Yoon J;Park SI;Bang SY;Nam Y;Walicki MC;Samineni VK;Mickle AD;Lee K;Heo SY;McCall JG;Pan T;Wang L;Feng X;Kim TI;Kim JK;Li Y;Huang Y;Gereau RW 4th;Ha JS;Bruchas MR;Rogers JA
体内光遗传学提供了独特的，强大的能力，在神经回路的解剖涉及神经精神疾病。然而，用于此类研究的常规硬件将实验动物物理地拴在外部光源上，限制了可能的实验范围。新兴的无线选项提供了避免这些限制中的一些的重要能力，但是当前的尺寸、体积、重量和无线覆盖区域通常是不利的。在这里，我们提出了一个简单但功能强大的设置，基于无线，近场功率传输和小型化，薄的灵活的光电植入物，在各种行为模式的完整的光学控制。该设备结合了联合收割机皮下磁线圈天线连接到微型，可注射的LED，能够在波长范围从紫外线到蓝色，绿色/黄色和红色。外部环形天线允许在众多行为装置中的鲁棒的、直接的应用。其结果是一种易于大规模生产，用户友好的技术，具有广泛的光遗传学应用潜力。
In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source limiting the range of possible experiments. Emerging wireless options offer important capabilities that avoid some of these limitations, but the current size, bulk, weight, and wireless area of coverage is often disadvantageous. Here, we present a simple but powerful setup based on wireless, near-field power transfer and miniaturized, thin flexible optoelectronic implants, for complete optical control in a variety of behavioral paradigms. The devices combine subdermal magnetic coil antennas connected to microscale, injectable LEDs, with the ability to operate at wavelengths ranging from ultraviolet to blue, green/yellow, and red. An external loop antenna allows robust, straightforward application in a multitude of behavioral apparatuses. The result is a readily mass-producible, user-friendly technology with broad potential for optogenetics applications.