Too much folate: a risk factor for cancer and cardiovascular disease?
Too much folate: a risk factor for cancer and cardiovascular disease?
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DOI：
10.1097/mco.0b013e32831cec62
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发表时间：
2009-01
影响因子：
3.1
通讯作者：
Choi SW
中科院分区：
文献类型：
--
作者：
Sauer J;Mason JB;Choi SW
The intent of this evidence-based review is to analyze the role of folate in chronic diseases, focusing on cancer and cardiovascular disease. Low folate status has been shown to be a risk factor for cancer and cardiovascular disease. While epidemiological data suggest an inverse association between folate status and disease risk, intervention studies give equivocal results, suggesting the response to folate intake does not follow a linear continuum. Moreover, recent folate intervention trials raise concern about possible adverse effects of folate supplementation and suggest that too much folate in inopportune settings may be potentially harmful in individuals at higher risk for cardiovascular disease and cancer. Although folate intake at sufficient levels appears to be an effective cancer chemopreventive strategy, high dose supplementation of folate has not been effective in reducing recurrence of cardiovascular events or colorectal adenomas in clinical intervention trials. Although controversial, high folate status achieved through folate fortification or supplementation may increase the risk of certain chronic diseases among certain individuals, possibly by interfering with the homeostasis of one-carbon metabolism. Further research is urgently needed to accurately define the relationship between supraphysiological intake of folate and chronic diseases.
