A familial component to human rectal cancer, independent of colon cancer risk
A familial component to human rectal cancer, independent of colon cancer risk
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DOI：
10.1016/j.cgh.2007.04.025
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发表时间：
2007-09-01
影响因子：
12.6
通讯作者：
Cannon-Albright, Lisa A.
中科院分区：
文献类型：
--
作者：
Maul, John Scott;Burt, Randall W.;Cannon-Albright, Lisa A.
背景和目标：犹他州人口数据库 (UPDB) 是独一无二的；它将犹他州超过 200 万个人的家谱与全州癌症登记处联系起来。我们研究了直肠癌的家族性，将其与结肠癌分开考虑。方法：我们使用 UPDB 的匹配对照估计直肠癌患者亲属的相对风险和平均相关性。结果：直肠癌患者的一级亲属患直肠癌的风险显着增加（相对风险[RR]，1.97），相当于结肠癌的风险（RR，2.11）。直肠癌风险的显着增加延伸到二级和三级亲属。年轻发病的直肠癌患者（< 55 岁）的一级亲属患直肠癌的 RR（RR，3.34）与其患结肠癌的风险（RR，3.35）相当。结论：UPDB 为直肠癌的家族因素提供了强有力的证据，除了共同环境之外，可能还包括遗传因素。直肠癌患者的近亲和远亲患直肠癌的风险显着增加，年轻发病患者的亲属患直肠癌的风险更高。尽管有报道称结肠癌先证者的亲属患结直肠癌的风险增加，但直肠癌患者亲属患大肠癌的风险尚不清楚。直肠癌先证者的亲属患大肠癌的风险至少与之前报道的结肠癌患者亲属的风险一样高。
Background & Aims: The Utah Population Database (UPDB) is unique; it links genealogy for over 2 million Utah individuals to a statewide Cancer Registry. We have investigated the familial nature of rectal cancer, considered independently from colon cancer. Methods: We estimated relative risks in relatives, and average relatedness among rectal cancer patients using matched controls from the UPDB. Results: There is a significant increased risk for rectal cancer in first-degree relatives of rectal cancer patients (relative risk [RR], 1.97), equivalent to the risk for colon cancer (RR, 2.11). The significant increased risk for rectal cancer extends to second- and third-degree relatives. The RR for rectal cancer among first-degree relatives of young-onset rectal cancer patients (< 55 y), is equivalent (RR, 3.34) to their risk of colon cancer (RR, 3.35). Conclusions: The UPDB provides strong evidence for a familial component to rectal cancer that may include a genetic component in addition to shared environment. There is a significant increased risk of rectal cancer in the close and distant relatives of rectal cancer patients, which is even higher among relatives of young-onset patients. Although it has been reported that relatives of colon cancer probands are at increased risk for colorectal cancer, the risk of large-bowel cancer among relatives of rectal cancer patients has been less clear. Relatives of rectal cancer probands experience a risk of cancer of the large bowel that is at least as high as the risk previously reported for relatives of individuals with colon cancer.