The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis.
The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis.
复制标题
乳腺癌淋巴管密度、淋巴管侵犯和淋巴结转移的关系：系统评价和荟萃分析
DOI：
10.18632/oncotarget.13752
复制
发表时间：
2017-01-10
期刊：
影响因子：
--
通讯作者：
Zou L
中科院分区：
文献类型：
--
作者：
Zhang S;Zhang D;Yi S;Gong M;Lu C;Cai Y;Tang X;Zou L
淋巴结状态是判断乳腺癌进展阶段的关键参数之一。淋巴管密度(LVD)、淋巴管侵袭(LVI)和淋巴结转移(LNM)之间的关系尚不清楚。检索PubMed、Embase和Web of Science的数据库，从最初到2016年5月25日。用Spearman相关系数(R)和95%可信区间(CI)来确定各组间的关系。根据预先设定的纳入标准，这项研究纳入了28项研究，涉及2920名乳腺癌患者。LVD-LVI、LVD-LNM和LVI-LNM的r值分别为0.45(95%CI：0.31~0.57)、0.32(95%CI：0.23~0.40)和0.24(95%CI：0.19~0.28)。与瘤内LVD相比，瘤周LVD与LVI(r=0.53，95%CI：0.27~0.72)和LNM(r=0.33，95%CI：0.18~0.46)具有更强的相关性。LNM阳性组的LVI检出率较高，为45.85%，而LNM阴性组的LVI检出率为23.85%。这些结果描述了乳腺癌中LVD、LVI和LNM之间的三角关系。LVD和LVI都是预测LNM发生的有价值的指标。与瘤内淋巴管相比，瘤周淋巴管可能是乳腺肿瘤细胞的主要传播途径。
Lymph node status is one of the key parameters used for determining the stage of breast cancer progression. The relationship of lymphatic vessel density (LVD), lymphovascular invasion (LVI), and lymph node metastasis (LNM) has not been clearly demonstrated yet. Databases of PubMed, Embase, and Web of Science were searched from inception up to 25 May 2016. Spearman correlation coefficient (r) and 95% confidence interval (CI) were used to determine the relationship within each group. Based on pre-established inclusion criteria, 28 studies involving 2920 breast cancer patients were included in this study. The r values of LVD-LVI, LVD-LNM, and LVI-LNM were 0.45 (95% CI: 0.31 to 0.57), 0.32 (95% CI: 0.23 to 0.40), and 0.24 (95% CI: 0.19 to 0.28), respectively. Compared with intratumoral LVD, peritumoral LVD showed more robust correlation with LVI (r = 0.53, 95% CI: 0.27 to 0.72) and LNM (r = 0.33, 95% CI: 0.18 to 0.46). The patients in LNM positive group presented with higher LVI detection rate of 45.85%, while in LNM negative group with detection rate of 23.85%. The results describe a triangle relationship between LVD, LVI, and LNM in breast cancer. Both LVD and LVI are indicated to be valuable predictors of LNM occurrence. Compared with intratumoral lymphatic vessels, peritumoral lymphatics might be the main disseminate route for breast tumor cells.