Relation between admission plasma fibrinogen levels and mortality in Chinese patients with coronary artery disease.
Relation between admission plasma fibrinogen levels and mortality in Chinese patients with coronary artery disease.
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中国冠心病患者入院血浆纤维蛋白原水平与死亡率的关系
DOI：
10.1038/srep30506
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发表时间：
2016-07-26
影响因子：
4.6
通讯作者：
Huang DJ
中科院分区：
文献类型：
--
作者：
Peng Y;Wang H;Li YM;Huang BT;Huang FY;Xia TL;Chai H;Wang PJ;Liu W;Zhang C;Chen M;Huang DJ
纤维蛋白原(Fib)被认为是冠心病(CAD)患者预后的潜在危险因素，但缺乏中国当代人群的证据。入选经冠状动脉造影术证实的冠心病患者30 2 0例，按预测全因死亡的最佳纤维蛋白分界值(3.17 g/L)分为2组。终点为全因死亡率和心源性死亡率。累积生存曲线显示，FIB≥3.17 g/L患者全因死亡的风险显著高于FIB<；3.17 g/L患者(死亡率，11.5%vs.5.7%，p<； 0.001)；心血管死亡率结果与上述结果相似(心脏死亡率5.9%vs.3.6%，p= 0.002)。亚组分析显示，根据年龄、病史和诊断，Fib水平升高可以预测亚组中全因死亡的风险。COX多元回归分析显示，在调整多个心血管危险因素(全因死亡率，HR2.01，CI1.51-2.68，P<； 0.001)后，血浆纤维蛋白原水平仍与全因死亡率独立相关。这项研究发现，纤维蛋白原水平与中国冠心病患者的死亡风险独立相关。
Fibrinogen (Fib) was considered to be a potential risk factor for the prognosis of patients with coronary artery disease (CAD), but there was lack of the evidence from Chinese contemporary population. 3020 consecutive patients with CAD confirmed by coronary angiography were enrolled and were grouped into 2 categories by the optimal Fib cut-off value (3.17 g/L) for all-cause mortality prediction. The end points were all-cause mortality and cardiac mortality. Cumulative survival curves showed that the risk of all-cause mortality was significantly higher in patients with Fib ≥3.17 g/L compared to those with Fib <3.17 g/L (mortality rate, 11.5% vs. 5.7%,p< 0.001); and cardiovascular mortality obtained results similar to those mentioned above (cardiac mortality rate, 5.9% vs. 3.6%,p= 0.002). Subgroup analysis showed that elevated Fib levels were predictive for the risk of all-cause mortality in the subgroups according to age, medical history and diagnosis. COX multivariate regression analysis showed that plasma Fib levels remained independently associated with all-cause mortality after adjustment for multiple cardiovascular risk factors (all-cause mortality, HR 2.01, CI 1.51–2.68,p< 0.001). This study has found that Fib levels were independently associated with the mortality risk in Chinese CAD patients.