Assessing bone health in children and adolescents.
Assessing bone health in children and adolescents.
复制标题
DOI：
10.4103/2230-8210.104040
复制
发表时间：
2012-12-01
影响因子：
--
通讯作者：
Levine, Michael A
中科院分区：
文献类型：
--
作者：
Levine, Michael A
在正常的童年和青春期，骨骼经历了巨大的变化。利用建模和重塑过程，骨骼获得其成人构型并最终达到峰值骨量。峰值骨量的优化需要环境、饮食、激素和遗传影响的适当相互作用。各种急性和慢性疾病以及遗传多态性与骨密度降低有关，这可能导致儿童期和成年期骨折风险增加。骨密度测定在成人骨疾病的评估中具有既定的作用，并且为儿童开发合适的参考范围现在允许将该技术应用于更年轻的个体。我们提出了一个简短的概述的因素，确定骨密度和骨密度测定在评估生长的儿童和青少年的骨量的新兴作用。
During normal childhood and adolescence, the skeleton undergoes tremendous change. Utilizing the processes of modeling and remodeling, the skeleton acquires its adult configuration and ultimately achieves peak bone mass. Optimization of peak bone mass requires the proper interaction of environmental, dietary, hormonal, and genetic influences. A variety of acute and chronic conditions, as well as genetic polymorphisms, are associated with reduced bone density, which can lead to an increased risk of fracture both in childhood and later during adulthood. Bone densitometry has an established role in the evaluation of adults with bone disorders, and the development of suitable reference ranges for children now permits the application of this technology to younger individuals. We present a brief overview of the factors that determine bone density and the emerging role of bone densitometry in the assessment of bone mass in growing children and adolescents.