The human gut microbiome: implications for future health care.
The human gut microbiome: implications for future health care.
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DOI：
10.1007/s11894-008-0075-y
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发表时间：
2008-08-01
影响因子：
--
通讯作者：
Nicholson, Jeremy K
中科院分区：
文献类型：
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作者：
Kinross, James M;von Roon, Alexander C;Nicholson, Jeremy K
在肠道中，人类拥有数百万微生物基因的“扩展基因组”-微生物组。由于这种复杂的共生关系影响着宿主的新陈代谢、生理和基因表达，因此有人提出人类是复杂的生物“超级有机体”。“微生物学分析和系统生物学的进展现在开始将肠道微生物组与肠易激综合征、炎症性肠病和结肠癌等局部肠道疾病的病因联系起来。这些方法还表明肠道与先前无关的全身性疾病（如2型糖尿病和肥胖症）之间可能存在联系。因此，肠道微生物组的阐明可能会支持未来的疾病预防策略，个性化的医疗保健方案和新型治疗干预措施的开发。这篇综述总结了定义我们对肠道微生物组的理解的研究，并强调了肠道微生物组将发挥重要作用的胃肠病学和人类健康研究的未来领域。
In their intestine, humans possess an "extended genome" of millions of microbial genes-the microbiome. Because this complex symbiosis influences host metabolism, physiology, and gene expression, it has been proposed that humans are complex biologic "superorganisms." Advances in microbiologic analysis and systems biology are now beginning to implicate the gut microbiome in the etiology of localized intestinal diseases such as the irritable bowel syndrome, inflammatory bowel disease, and colon cancer. These approaches also suggest possible links between the gut and previously unassociated systemic conditions such as type 2 diabetes and obesity. The elucidation of the intestinal microbiome is therefore likely to underpin future disease prevention strategies, personalized health care regimens, and the development of novel therapeutic interventions. This review summarizes the research that is defining our understanding of the intestinal microbiome and highlights future areas of research in gastroenterology and human health in which the intestinal microbiome will play a significant role.