Mild rhodium(III)-catalyzed C-H allylation with 4-vinyl-1,3-dioxolan-2-ones: direct and stereoselective synthesis of (E)-allylic alcohols.
Mild rhodium(III)-catalyzed C-H allylation with 4-vinyl-1,3-dioxolan-2-ones: direct and stereoselective synthesis of (E)-allylic alcohols.
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DOI：
10.1021/ol503229c
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发表时间：
2014-12
期刊：
影响因子：
5.2
通讯作者：
Shang‐Shi Zhang;Jia-Qiang Wu;Y. Lao;Xu-Ge Liu;Yaohong Liu;Wen-Xin Lv;Dong‐Hang Tan;Yao‐Fu Zeng-Yao‐Fu-Zen
中科院分区：
文献类型：
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作者：
Shang‐Shi Zhang;Jia-Qiang Wu;Y. Lao;Xu-Ge Liu;Yaohong Liu;Wen-Xin Lv;Dong‐Hang Tan;Yao‐Fu Zeng-Yao‐Fu-Zen
开发了铑(III)催化的与4-乙烯基-1,3-二氧戊环-2-酮的C-H直接烯丙基化反应。该反应在温和和氧化还原中性的反应条件下提供了一种简便且立体选择性的取代-(E)-烯丙醇的制备方法。适用于烯烃 C-H 活化，以良好的产率得到多功能化的跳跃二烯。观察到最小的双键迁移。
A rhodium(III)-catalyzed C-H direct allylation reaction with 4-vinyl-1,3-dioxolan-2-ones has been developed. The reaction provides a facile and stereoselective access to substituted-(E)-allylic alcohols under mild and redox-neutral reaction conditions. Olefinic C-H activation is applicable, giving multifunctionalized skipped dienes in good yields. Minimal double-bond migration was observed.