All-optical phase modulation for integrated interferometric biosensors
All-optical phase modulation for integrated interferometric biosensors
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DOI：
10.1364/oe.20.007195
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发表时间：
2012-03-26
期刊：
影响因子：
3.8
通讯作者：
Lechuga, Laura M.
中科院分区：
文献类型：
--
作者：
Dante, Stefania;Duval, Daphne;Lechuga, Laura M.
为了解决干涉信号的周期性问题，提出了一种在集成马赫-曾德尔干涉仪中实现全光相位调制系统的理论和实验方案。通过改变低成本商用激光二极管的输出功率来调制其发射波长来调节传感器的相位。信号的FFT去卷积允许直接读出相位，不受灵敏度变化和光强波动的影响。这种简单的相位调制方案将测量的信噪比提高了一个数量级，呈现在传感器中，检测下限为1.9。10(-7)RIU。全光调制方法的可行性被用免疫分析检测作为生物传感概念的证明来证明。(C)2012年美国光学学会
We present the theoretical and the experimental implementation of an all-optical phase modulation system in integrated Mach-Zehnder Interferometers to solve the drawbacks related to the periodic nature of the interferometric signal. Sensor phase is tuned by modulating the emission wavelength of low-cost commercial laser diodes by changing their output power. FFT deconvolution of the signal allows for direct phase readout, immune to sensitivity variations and to light intensity fluctuations. This simple phase modulation scheme increases the signal-to-noise ratio of the measurements in one order of magnitude, rendering in a sensor with a detection limit of 1.9. 10(-7) RIU. The viability of the all-optical modulation approach is demonstrated with an immunoassay detection as a biosensing proof of concept. (C) 2012 Optical Society of America