Elective transfer of two embryos: Reduction of multiple gestations while maintaining high pregnancy rates
Elective transfer of two embryos: Reduction of multiple gestations while maintaining high pregnancy rates
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DOI：
10.1007/s10815-006-9085-6
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发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Oehninger, Sergio
中科院分区：
文献类型：
--
作者：
Dowling-Lacey, Donna;Jones, Estella;Oehninger, Sergio
目的：确定选择性移植两个胚胎是否能在保持高妊娠率的同时降低多胎妊娠的发生率。方法：对体外受精患者和选择性移植2~3个胚胎的卵子捐献者进行研究。结果(S)：在体外受精中，选择性移植2枚胚胎的妊娠率与选择性移植3枚胚胎的妊娠率相似，但多胎妊娠的发生率显著低于选择性移植3枚胚胎的妊娠率(20%比39%)。双胞胎妊娠率从28%下降到19%，三胞胎从9%显著下降到1%。在卵母细胞捐献方面，选择性移植2个胚胎的妊娠率相似，但也显著降低了多胎妊娠的总体发生率(26%对48%)，双胞胎从34%减少到24%，三胞胎显著减少(13%对2%)。结论：在体外受精和卵母细胞移植中，选择性移植2枚胚胎的妊娠率与选择性移植3枚胚胎相比，妊娠率相近，多胎妊娠率显著降低。
Purpose: To determine if the elective transfer of two embryos reduced the incidence of multiple gestations while maintaining high pregnancy rates. Methods: IVF patients and recipients of oocyte donation with an elective day-3 transfer of 2 or 3 embryos were studied. Result(s): In IVF, the elective transfer of 2 embryos resulted in similar pregnancy rate but significantly reduced the overall incidence of multiple gestations (20% versus 39%) when compared to the elective transfer of 3 embryos. Twin gestations decreased from 28% to 19%, and triplets significantly decreased from 9% to 1%. In oocyte donation, the elective transfer of 2 embryos resulted in similar pregnancy rate but also significantly reduced the overall incidence of multiple gestations (26% versus 48%), with twins decreasing from 34% to 24%, and with a significant reduction of triplets (13% versus 2%). Conclusions: In IVF and oocyte donation, the elective transfer of 2 embryos resulted in similar pregnancy rates and significantly reduced multiple gestation rates when compared to the elective transfer of 3 embryos.