The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
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DOI：
10.4142/jvs.2011.12.1.65
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发表时间：
2011-03
影响因子：
1.8
通讯作者：
Parlak U
中科院分区：
文献类型：
--
作者：
Gulbahar MY;Kabak YB;Karayigit MO;Yarim M;Guvenc T;Parlak U
本研究探讨了热休克蛋白70 （HSP70）和α-碱性结晶蛋白（α-BC）在口蹄疫病毒（FMDV）诱导的羔羊心肌炎发病过程中的表达及其与细胞凋亡和一些相关衔接蛋白的关系。与非口蹄疫控制心脏相比，HSP70在口蹄疫诱导的心肌炎心肌组织和炎症细胞中普遍过表达，但在同一心脏的积累和定位存在差异。α-BC免疫标记显示，与对照组相比，fmdv感染心脏的心肌细胞在Z线上有粗聚集。综上所述，本研究结果表明，在fmdv感染的心脏组织中，抗凋亡蛋白HSP70和α-BC过表达，凋亡增加。在感染期间，这两种蛋白都不能作为FMDV的防御机制保护心肌细胞免于凋亡，这表明病毒能够通过下调和/或上调这些抗凋亡蛋白来增加细胞凋亡。
This study describes the expression of heat shock protein70 (HSP70) and alpha-basic-crystallin (α-BC) and their association with apoptosis and some related adaptor proteins in the pathogenesis of foot-and-mouth disease virus (FMDV)-induced myocarditis in lambs. HSP70 was generally overexpressed in the myocardial tissues and inflammatory cells of FMDV-induced myocarditis with differential accumulation and localization in same hearts when compared to non-foot-and-mouth disease control hearts. α-BC immunolabeling showed coarse aggregations in the Z line of the cardiomyocytes in FMDV-infected hearts in contrast to control hearts. Overall, the results of this study show that the anti-apoptotic proteins, HSP70 and α-BC, were overexpressed with increased apoptosis in FMDV-infected heart tissues. Both proteins failed to protect the cardiomyocytes from apoptosis as defense mechanisms to the FMDV during the infection, suggesting that the virus is able to increase apoptosis via both downregulation and/or upregulation of these anti-apoptotic proteins.
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