SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes
SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes
复制标题
SP-A 作为细胞因子：表面活性蛋白 A 调节表面活性蛋白和其他基因的转录
DOI：
--
复制
发表时间：
1999
影响因子：
5.6
通讯作者：
D. Strayer
中科院分区：
文献类型：
--
作者：
L. Korutla;D. Strayer
Pulmonary surfactant is a mixture of phospholipids and surfactant‐associated proteins made by alveolar type II cells that is necessary for normal lung function. Surfactant secretion and reuptake by type II cells are regulated in part by interaction of surfactant protein‐A (SP‐A) with a specific receptor (SPAR) on type II cells. Several chemicals and hormones affect both surfactant secretion and also surfactant gene expression, but consequences of SP‐A–SPAR interaction beyond regulating surfactant secretion and reuptake are unknown. Accordingly, we studied the effects of SP‐A on surfactant protein gene transcription, mRNA levels, and transcript stability. SP‐A elicited new transcription of surfactant proteins SP‐A, SP‐B, and SP‐C and SPAR and c‐Jun but had no effect on β‐actin or c‐fos transcription. Antibody against SP‐A receptor blocked SP‐A–induced transcription, confirming that these actions of SP‐A were receptor‐mediated. SP‐A effects on overall transcript levels were more complex. However, SP‐A, SP‐B, and SP‐C mRNA levels doubled in SP‐A–treated cells compared to controls. SP‐A is known to stabilize surfactant, control its secretion and reuptake by type II cells, and augment host antimicrobial defenses. These data indicate that SP‐A also acts as an autocrine cytokine: it binds its receptor and specifically regulates transcription of surfactant proteins and other genes. J. Cell. Physiol. 178:379–386, 1999. © 1999 Wiley‐Liss, Inc.
登录
查看更多内容
碱中毒和 ATP 诱导的 II 型肺泡细胞中二酰甘油池的增加源自磷脂酰胆碱和磷脂酰肌醇。
DOI：
10.1042/bj2980681
发表时间：
1994
期刊：
The Biochemical journal
影响因子：
--
作者：
Sen,N;Chander,A
通讯作者：
Chander,A
影响因子：
4.4
作者：
C. D. Gaynor;F. X. McCormack;D. Voelker;S. McGowan;L. Schlesinger
通讯作者：
C. D. Gaynor;F. X. McCormack;D. Voelker;S. McGowan;L. Schlesinger
DOI：
10.1016/s0021-9258(18)69159-8
发表时间：
1988-02
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
V. Boggaram;K. Qing;C. Mendelson
通讯作者：
V. Boggaram;K. Qing;C. Mendelson
DOI：
10.1165/ajrcmb.17.6.2858
发表时间：
1997-12-01
影响因子：
6.4
作者：
Alcorn, JL;Smith, ME;Mendelson, CR
通讯作者：
Mendelson, CR
肺表面活性物质分泌的受体介导的调节。
DOI：
10.1006/excr.1996.0206
发表时间：
1996
期刊：
Experimental cell research.
影响因子：
--
作者：
Strayer,DS;Pinder,R;Chander,A
通讯作者：
Chander,A