BCL-2 proteins and apoptosis: Recent insights and unknowns
BCL-2 proteins and apoptosis: Recent insights and unknowns
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DOI：
10.1016/j.bbrc.2017.06.190
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发表时间：
2018-05-27
影响因子：
3.1
通讯作者：
Edlich, Frank
中科院分区：
文献类型：
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作者：
Edlich, Frank
b细胞淋巴瘤-2 （BCL-2）家族蛋白控制内在凋亡途径。促凋亡的BCL-2蛋白BAX和BAK可以通过通透线粒体外膜（OMM）和随后的caspase级联启动导致细胞程序性死亡。因此，BAX和BAK的活性受到BCL-2家族内外复杂的蛋白质网络的精确控制。细胞存活是通过不断控制BAX和BAK的动态易位和反易位到线粒体并返回细胞质。最近对BAX/BAK穿梭、BCL-2蛋白相互作用、BH3-only蛋白在凋亡信号传导中的作用和活性BAX复合物的研究为癌症治疗和细胞凋亡易感分析的新策略的发展奠定了基础。(C) 2017爱思唯尔公司版权所有。
Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway. The proapoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death by permeabilizing the outer mitochondrial membrane (OMM) and subsequent initiation of the caspase cascade. Therefore, the activities of BAX and BAK are precisely controlled by a complex network of proteins inside and outside the BCL-2 family. Cells survive by constant control of dynamic translocation and retrotranslocation of BAX and BAK to the mitochondria and back into the cytosol. Recent insights into BAX/BAK shuttling, BCL-2 protein interactions, the role of BH3-only proteins in apoptosis signaling and the active BAX complex set the stage for the development of novel strategies in cancer therapy and the analysis of cellular predisposition to apoptosis. (C) 2017 Elsevier Inc. All rights reserved.