Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma.
Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma.
复制标题
卵巢癌中二肽基肽酶 IV 过度表达可延长生存期并降低侵袭活性。
作者：
H. Kajiyama;F. Kikkawa;Takahiro Suzuki;K. Shibata;K. Ino;S. Mizutani
二肽基肽酶IV（DPPIV）是一种多功能的细胞表面氨肽酶，广泛表达。最近的研究表明，DPPIV在几种人类恶性肿瘤的肿瘤进展中起重要作用。在本研究中，我们研究了DPPIV表达与卵巢癌进展潜力之间的相关性。我们证明，卵巢癌细胞系具有较高的DPPIV表达的侵袭性较低。此外，在SKOV 3细胞，来自浆液性囊腺癌，DPPIV表达很少诱导细胞形态的显着变化和迁移和侵袭能力的显着下降。此外，我们还发现，与接受亲本或仅载体转染细胞的裸鼠相比，接种DPPIV转染SKOV 3细胞的裸鼠腹膜播散明显减少，存活时间延长（平均存活时间分别为64.9 +/- 4.7、35.7 +/- 2.8和36.6 +/- 1.8天）。这一证据表明，DPPIV可能在功能上抑制卵巢癌的腹膜播散。
Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression. Recent studies have suggested that DPPIV plays an important role in tumor progression in several human malignancies. In the present study, we investigated the correlation between DPPIV expression and progressive potential in ovarian carcinoma. We demonstrated that ovarian carcinoma cell lines with higher DPPIV expression were less invasive. Furthermore, DPPIV overexpression in SKOV3 cells, derived from serous cystadenocarcinoma, with little DPPIV expression induced a dramatic change in cellular morphology and a significant decrease in the abilities of both migration and invasion. In addition, we have also shown that nude mice inoculated with DPPIV-transfected SKOV3 cells showed significantly less peritoneal dissemination and longer survival time than those receiving the parental or vector-only transfected cells (mean survival time, 64.9 +/- 4.7, 35.7 +/- 2.8, and 36.6 +/- 1.8 days, respectively). This evidence implies that DPPIV may functionally suppress peritoneal dissemination in ovarian carcinoma.
影响因子：
4.7
作者：
Lee, SW;Reimer, CL;Kocher, O
通讯作者：
Kocher, O