Glucagon physiology and pathophysiology.
Glucagon physiology and pathophysiology.
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胰高血糖素生理学和病理生理学。
DOI：
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发表时间：
1971
影响因子：
158.5
通讯作者：
R. Unger
中科院分区：
文献类型：
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作者：
R. Unger
几十年来，胰高血糖素的功能一直受到质疑，但现在看来，胰高血糖素很可能像胰岛素一样，在时刻控制葡萄糖、某些氨基酸甚至游离脂肪酸的稳态中极其重要。正常的α细胞功能似乎对于最佳的血糖调节至关重要，而异常的α细胞功能可能导致、促成或导致多种代谢紊乱，最常见的是糖尿病。胰高血糖素和胰岛素的生物对抗 胰高血糖素已被证明在生理范围内的浓度下具有有效的糖原分解1 和糖异生2 , 3 活性。此外，它还可能有 . 。 。
THE function of pancreatic glucagon has been questioned for several decades, but it now seems probable that glucagon, like insulin, is extremely important in the moment-to-moment control of the homeostasis of glucose, of certain amino acids and perhaps of free fatty acids. Normal alpha-cell function seems essential to optimal glucoregulation, and abnormal alpha-cell function may cause, contribute to or result from a variety of metabolic disorders, the most common being diabetes mellitus. Biologic Opposition of Glucagon and Insulin Glucagon has been shown to have potent glycogenolytic1 and gluconeogenic2 , 3 activity at concentrations within the physiologic range. In addition, it may have . . .